Longitudinal changes in social functioning in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: Results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)

Francesco Patti, Maria Pia Amato, Maria Trojano, Stefano Bastianello, Maria Rosalia Tola, Orietta Picconi, Sabina Cilia, Salvatore Cottone, Luigi M E Grimaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To report longitudinal changes in and explore the influence of cognition on social functioning in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS). Methods Italian patients (18-50 years) with RRMS and Expanded Disability Status Scale (EDSS) score ≤4.0 were assigned to interferon β-1a, 44 or 22 μg subcutaneously three times weekly, and underwent annual assessments for social functioning (Environmental Status Scale [ESS]) over 3 years. Results Baseline total ESS score did not differ between patients with and without cognitive impairment (P = 0.505). Total ESS score remained low (

Original languageEnglish
Pages (from-to)1111-1121
Number of pages11
JournalQuality of Life Research
Volume21
Issue number7
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Cognitive function
  • Interferon b-1a
  • Quality of life
  • Relapsing-remitting multiple sclerosis
  • Social interaction
  • Social isolation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

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