Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging

Angelo Scuteri, Christopher H. Morrell, Marco Orrù, James B. Strait, Kirill V. Tarasov, Liana Anna Pina Ferreli, Francesco Loi, Maria Grazia Pilia, Alessandro Delitala, Harold Spurgeon, Samer S. Najjar, Majd Alghatrif, Edward G. Lakatta

Research output: Contribution to journalArticlepeer-review

Abstract

The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 communitydwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages

Original languageEnglish
Pages (from-to)1219-1227
Number of pages9
JournalHypertension
Volume64
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Aging
  • Arteries
  • Blood pressure
  • Longitudinal studies
  • Pulse wave analysis
  • Sex

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

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