Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors

Christina Broström; Ubaldo Visco-Comandini; Zhibing Yun; Anders Sönnerborg

doi:10.1086/314757

Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors

Christina Broström, Ubaldo Visco-Comandini, Zhibing Yun, Anders Sönnerborg

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty patients with human immunodeficiency virus type 1 (HIV-1) infection for >7 years, no HIV-1-related symptoms, no treatment, and CD4⁺ cell counts >500/μL were included in a prospective study in 1993. Four years later, 12 patients had progressed (SPs), while 8 had not (long-term nonprogressors [LTNPs]). At inclusion, HIV-1 RNA, but not DNA, levels were higher in SPs. During follow-up, a consistent increase in HIV-1 RNA was seen in only 1 LTNP. In 2 LTNPs, plasma viremia was persistently undetectable or

Original language	English
Pages (from-to)	1542-1548
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	179
Issue number	6
DOIs	https://doi.org/10.1086/314757
Publication status	Published - 1999

ASJC Scopus subject areas

Immunology
Public Health, Environmental and Occupational Health

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