Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

Annika Antonsson, Tim Waterboer, Jan N. Bouwes Bavinck, Damiano Abeni, Maurits de Koning, Sylvie Euvrard, Mariet C W Feltkamp, Adèle C. Green, Catherine A. Harwood, Luigi Naldi, Ingo Nindl, Herbert J. Pfister, Charlotte M. Proby, Wim G. Quint, Eggert Stockfleth, Sönke J. Weissenborn, Michael Pawlita, Rachel E. Neale

Research output: Contribution to journalArticlepeer-review

Abstract

Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalVirology
Volume436
Issue number1
DOIs
Publication statusPublished - Feb 5 2013

Keywords

  • Antibody stability
  • Human papillomavirus
  • Longitudinal study
  • Organ transplanted recipients
  • Serology
  • Seroprevalence

ASJC Scopus subject areas

  • Virology

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