Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies

Stefano Tabolli, Patrizia Giannantoni, Federica Pulvirenti, Fabiola La Marra, Guido Granata, Cinzia Milito, Isabella Quinti

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of CVID patients in a longitudinal study over a 6-year period by a generic, non-disease-specific instrument (SF-36), and by a General Health Questionnaire (GHQ-12) for the risk of depression/anxiety. At baseline, 96 patients were enrolled. After 1 year, a second assessment was performed on 92 patients and, after 6 years, a third assessment was performed on 66 patients. Eighteen patients died during the study time. HRQoL was low, with mental health scales less affected than physical scales. A decline in the score on SF-36 scales was observed between the first and the third assessment for the Physical Functioning, Body Pain, General Health, Social Functioning, and Role-Emotional scales. The General Health scale showed a lower score in these patients, when compared to patients with other chronic diseases. Approximately one-third of the patients were at risk of anxiety/depression at all observation times, a percentage that reached two thirds of the patients, considering only the group of females. Over the 6 years of the study, the health condition of 11/66 patients worsened, passing from "GHQ-negative" to "GHQ-positive" their score on SF-36 scales also decreased. A decrement of one point in each of the Physical Functioning, Vitality, Social Functioning, and Mental Health SF-36 scales increased the risk of developing anxiety/depression from three to five percent. A negative variation of the Physical Functioning score increased the risk of psychological distress. In a survival analysis with dichotomized variables, Physical Functioning scores

Original languageEnglish
Article number605
JournalFrontiers in Immunology
Volume5
Issue numberNOV
DOIs
Publication statusPublished - 2014

Fingerprint

Common Variable Immunodeficiency
Longitudinal Studies
Quality of Life
Anxiety
Health
Depression
Mental Health
Psychology
Survival Analysis
Immunoglobulins
Appointments and Schedules
Chronic Disease
Observation

Keywords

  • Common variable immune deficiencies
  • GHQ-12
  • Health-related quality of life
  • Immunoglobulins
  • Sf-36

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Tabolli, S., Giannantoni, P., Pulvirenti, F., La Marra, F., Granata, G., Milito, C., & Quinti, I. (2014). Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies. Frontiers in Immunology, 5(NOV), [605]. https://doi.org/10.3389/fimmu.2014.00605

Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies. / Tabolli, Stefano; Giannantoni, Patrizia; Pulvirenti, Federica; La Marra, Fabiola; Granata, Guido; Milito, Cinzia; Quinti, Isabella.

In: Frontiers in Immunology, Vol. 5, No. NOV, 605, 2014.

Research output: Contribution to journalArticle

Tabolli, S, Giannantoni, P, Pulvirenti, F, La Marra, F, Granata, G, Milito, C & Quinti, I 2014, 'Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies', Frontiers in Immunology, vol. 5, no. NOV, 605. https://doi.org/10.3389/fimmu.2014.00605
Tabolli, Stefano ; Giannantoni, Patrizia ; Pulvirenti, Federica ; La Marra, Fabiola ; Granata, Guido ; Milito, Cinzia ; Quinti, Isabella. / Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies. In: Frontiers in Immunology. 2014 ; Vol. 5, No. NOV.
@article{87f2b67dd7f249678645ff889018dcfb,
title = "Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies",
abstract = "Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of CVID patients in a longitudinal study over a 6-year period by a generic, non-disease-specific instrument (SF-36), and by a General Health Questionnaire (GHQ-12) for the risk of depression/anxiety. At baseline, 96 patients were enrolled. After 1 year, a second assessment was performed on 92 patients and, after 6 years, a third assessment was performed on 66 patients. Eighteen patients died during the study time. HRQoL was low, with mental health scales less affected than physical scales. A decline in the score on SF-36 scales was observed between the first and the third assessment for the Physical Functioning, Body Pain, General Health, Social Functioning, and Role-Emotional scales. The General Health scale showed a lower score in these patients, when compared to patients with other chronic diseases. Approximately one-third of the patients were at risk of anxiety/depression at all observation times, a percentage that reached two thirds of the patients, considering only the group of females. Over the 6 years of the study, the health condition of 11/66 patients worsened, passing from {"}GHQ-negative{"} to {"}GHQ-positive{"} their score on SF-36 scales also decreased. A decrement of one point in each of the Physical Functioning, Vitality, Social Functioning, and Mental Health SF-36 scales increased the risk of developing anxiety/depression from three to five percent. A negative variation of the Physical Functioning score increased the risk of psychological distress. In a survival analysis with dichotomized variables, Physical Functioning scores",
keywords = "Common variable immune deficiencies, GHQ-12, Health-related quality of life, Immunoglobulins, Sf-36",
author = "Stefano Tabolli and Patrizia Giannantoni and Federica Pulvirenti and {La Marra}, Fabiola and Guido Granata and Cinzia Milito and Isabella Quinti",
year = "2014",
doi = "10.3389/fimmu.2014.00605",
language = "English",
volume = "5",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",
number = "NOV",

}

TY - JOUR

T1 - Longitudinal study on health-related quality of life in a cohort of 96 patients with common variable immune deficiencies

AU - Tabolli, Stefano

AU - Giannantoni, Patrizia

AU - Pulvirenti, Federica

AU - La Marra, Fabiola

AU - Granata, Guido

AU - Milito, Cinzia

AU - Quinti, Isabella

PY - 2014

Y1 - 2014

N2 - Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of CVID patients in a longitudinal study over a 6-year period by a generic, non-disease-specific instrument (SF-36), and by a General Health Questionnaire (GHQ-12) for the risk of depression/anxiety. At baseline, 96 patients were enrolled. After 1 year, a second assessment was performed on 92 patients and, after 6 years, a third assessment was performed on 66 patients. Eighteen patients died during the study time. HRQoL was low, with mental health scales less affected than physical scales. A decline in the score on SF-36 scales was observed between the first and the third assessment for the Physical Functioning, Body Pain, General Health, Social Functioning, and Role-Emotional scales. The General Health scale showed a lower score in these patients, when compared to patients with other chronic diseases. Approximately one-third of the patients were at risk of anxiety/depression at all observation times, a percentage that reached two thirds of the patients, considering only the group of females. Over the 6 years of the study, the health condition of 11/66 patients worsened, passing from "GHQ-negative" to "GHQ-positive" their score on SF-36 scales also decreased. A decrement of one point in each of the Physical Functioning, Vitality, Social Functioning, and Mental Health SF-36 scales increased the risk of developing anxiety/depression from three to five percent. A negative variation of the Physical Functioning score increased the risk of psychological distress. In a survival analysis with dichotomized variables, Physical Functioning scores

AB - Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of CVID patients in a longitudinal study over a 6-year period by a generic, non-disease-specific instrument (SF-36), and by a General Health Questionnaire (GHQ-12) for the risk of depression/anxiety. At baseline, 96 patients were enrolled. After 1 year, a second assessment was performed on 92 patients and, after 6 years, a third assessment was performed on 66 patients. Eighteen patients died during the study time. HRQoL was low, with mental health scales less affected than physical scales. A decline in the score on SF-36 scales was observed between the first and the third assessment for the Physical Functioning, Body Pain, General Health, Social Functioning, and Role-Emotional scales. The General Health scale showed a lower score in these patients, when compared to patients with other chronic diseases. Approximately one-third of the patients were at risk of anxiety/depression at all observation times, a percentage that reached two thirds of the patients, considering only the group of females. Over the 6 years of the study, the health condition of 11/66 patients worsened, passing from "GHQ-negative" to "GHQ-positive" their score on SF-36 scales also decreased. A decrement of one point in each of the Physical Functioning, Vitality, Social Functioning, and Mental Health SF-36 scales increased the risk of developing anxiety/depression from three to five percent. A negative variation of the Physical Functioning score increased the risk of psychological distress. In a survival analysis with dichotomized variables, Physical Functioning scores

KW - Common variable immune deficiencies

KW - GHQ-12

KW - Health-related quality of life

KW - Immunoglobulins

KW - Sf-36

UR - http://www.scopus.com/inward/record.url?scp=84919442193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919442193&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2014.00605

DO - 10.3389/fimmu.2014.00605

M3 - Article

AN - SCOPUS:84919442193

VL - 5

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - NOV

M1 - 605

ER -