Longitudinal survey of T-lymphocytes and viral antibodies in MS patients.

D. Caputo, P. Ferrante, M. Zaffaroni, A. Ghezzi, C. L. Cazzullo

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Our study focused on the relationship between lymphocyte H/S ratios and antiviral antibodies. We have concluded a longitudinal survey of 29 clinically definite MS patients for 8 months seeking a possible correlation among clinical modifications, fluctuations of T-cell subsets and antiviral antibody titers. For this purpose in each patient the following parameters were recorded monthly:--clinical history and neurological examination;--blood T-cell subpopulation as defined by monoclonal antibodies of the OKT series;--serum antibody titers against measles, herpes simplex type 1 and 2, HTLV-1 viruses. All these data were compared with the different MS subgroups as defined by clinical course: stable, relapsing, progressive. We found that constantly normal OKT4+/OKT8+ ratios correlate with a stable clinical course; that highly fluctuating ratios parallel clinical exacerbation; that constantly high ratios are associated with a chronic-progressive course. These results are discussed with special reference to the correlation between OKT8+ lymphocyte percentages and anti-HTLV-1 antibodies, since this last virus has recently been claimed to be of pathogenetic importance in MS.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalItalian Journal of Neurological Sciences
VolumeSuppl 6
Publication statusPublished - Jun 1987

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Caputo, D., Ferrante, P., Zaffaroni, M., Ghezzi, A., & Cazzullo, C. L. (1987). Longitudinal survey of T-lymphocytes and viral antibodies in MS patients. Italian Journal of Neurological Sciences, Suppl 6, 53-56.