Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging

Majd AlGhatrif, James B. Strait, Chris H. Morrell, Marco Canepa, Jeanette Wright, Palchamy Elango, Angelo Scuteri, Samer S. Najjar, Luigi Ferrucci, Edward G. Lakatta

Research output: Contribution to journalArticle

Abstract

Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) ≥140 mm Hg but also SBP of 120 to 139 mm Hg was associated with steeper rates of PWV increase compared with SBP

Original languageEnglish
Pages (from-to)934-941
Number of pages8
JournalHypertension
Volume62
Issue number5
DOIs
Publication statusPublished - Nov 2013

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Keywords

  • aging
  • blood pressure
  • vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

AlGhatrif, M., Strait, J. B., Morrell, C. H., Canepa, M., Wright, J., Elango, P., Scuteri, A., Najjar, S. S., Ferrucci, L., & Lakatta, E. G. (2013). Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging. Hypertension, 62(5), 934-941. https://doi.org/10.1161/HYPERTENSIONAHA.113.01445