Abstract
Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) ≥140 mm Hg but also SBP of 120 to 139 mm Hg was associated with steeper rates of PWV increase compared with SBP
Original language | English |
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Pages (from-to) | 934-941 |
Number of pages | 8 |
Journal | Hypertension |
Volume | 62 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 2013 |
Keywords
- aging
- blood pressure
- vascular stiffness
ASJC Scopus subject areas
- Internal Medicine
- Medicine(all)