Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging

Majd AlGhatrif; James B. Strait; Chris H. Morrell; Marco Canepa; Jeanette Wright; Palchamy Elango; Angelo Scuteri; Samer S. Najjar; Luigi Ferrucci; Edward G. Lakatta

doi:10.1161/HYPERTENSIONAHA.113.01445

Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging

Majd AlGhatrif, James B. Strait, Chris H. Morrell, Marco Canepa, Jeanette Wright, Palchamy Elango, Angelo Scuteri, Samer S. Najjar, Luigi Ferrucci, Edward G. Lakatta

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) ≥140 mm Hg but also SBP of 120 to 139 mm Hg was associated with steeper rates of PWV increase compared with SBP

Original language	English
Pages (from-to)	934-941
Number of pages	8
Journal	Hypertension
Volume	62
Issue number	5
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.01445
Publication status	Published - Nov 2013

Keywords

aging
blood pressure
vascular stiffness

ASJC Scopus subject areas

Internal Medicine
Medicine(all)

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10.1161/HYPERTENSIONAHA.113.01445

Cite this

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title = "Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging",

abstract = "Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) ≥140 mm Hg but also SBP of 120 to 139 mm Hg was associated with steeper rates of PWV increase compared with SBP",

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AU - Canepa, Marco

AU - Wright, Jeanette

AU - Elango, Palchamy

AU - Scuteri, Angelo

AU - Najjar, Samer S.

AU - Ferrucci, Luigi

AU - Lakatta, Edward G.

PY - 2013/11

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AB - Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, we collected 2 to 9 serial measures of PWV in 354 men and 423 women of the Baltimore Longitudinal Study of Aging, who were 21 to 94 years of age and free of clinically significant cardiovascular disease. Rates of PWV increase accelerated with advancing age in men more than women, leading to sex differences in PWV after the age of 50 years. In both sexes, not only systolic blood pressure (SBP) ≥140 mm Hg but also SBP of 120 to 139 mm Hg was associated with steeper rates of PWV increase compared with SBP

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Longitudinal trajectories of arterial stiffness and the role of blood pressure: The Baltimore longitudinal study of aging

Abstract

Keywords

ASJC Scopus subject areas

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