Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

A. Floridi; M. G. Paggi; M. L. Marcante; B. Silvestrini; A. Caputo; C. De Martino

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

A. Floridi, M. G. Paggi, M. L. Marcante, B. Silvestrini, A. Caputo, C. De Martino

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.

Original language	English
Pages (from-to)	497-499
Number of pages	3
Journal	Journal of the National Cancer Institute
Volume	66
Issue number	3
Publication status	Published - 1981

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells",

abstract = "The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.",

author = "A. Floridi and Paggi, {M. G.} and Marcante, {M. L.} and B. Silvestrini and A. Caputo and {De Martino}, C.",

year = "1981",

language = "English",

volume = "66",

pages = "497--499",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

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T1 - Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

AU - Floridi, A.

AU - Paggi, M. G.

AU - Marcante, M. L.

AU - Silvestrini, B.

AU - Caputo, A.

AU - De Martino, C.

PY - 1981

Y1 - 1981

N2 - The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.

AB - The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.

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M3 - Article

C2 - 6937706

AN - SCOPUS:0019457193

VL - 66

SP - 497

EP - 499

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 3

ER -