Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

A. Floridi, M. G. Paggi, M. L. Marcante, B. Silvestrini, A. Caputo, C. De Martino

Research output: Contribution to journalArticlepeer-review

Abstract

The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.

Original languageEnglish
Pages (from-to)497-499
Number of pages3
JournalJournal of the National Cancer Institute
Volume66
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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