Lonidamine-induced membrane permeability and the effect of adriamycin on the energy metabolism of Ehrlich ascites tumor cells

A. Floridi, A. Bagnato, C. Bianchi, M. Fanciulli, B. Silvestrini, A. Caputo

Research output: Contribution to journalArticle

Abstract

It has been demonstrated that lonidamine (LND) potentiates the effect of adriamycin (ADM) by increasing membrane permeability of Ehrlich ascites tumor cells, thus allowing low ADM concentration (18 μM) to interfere also with oxidative metabolism. In order to establish whether the enhanced ADM susceptibility of LND-treated cells might be ascribed to a modified mitochondrial permeability, the effect of LND on cytochrome c oxygen reductase, a marker of the extent of outer mitochondrial membrane permeabilization, was evaluated.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume551
Publication statusPublished - 1988

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Ehrlich Tumor Carcinoma
Doxorubicin
Energy Metabolism
Tumors
Permeability
Cells
Membranes
Mitochondrial Membranes
Cytochromes c
Metabolism
Oxidoreductases
Oxygen
lonidamine
Energy
Membrane
Susceptibility

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lonidamine-induced membrane permeability and the effect of adriamycin on the energy metabolism of Ehrlich ascites tumor cells. / Floridi, A.; Bagnato, A.; Bianchi, C.; Fanciulli, M.; Silvestrini, B.; Caputo, A.

In: Annals of the New York Academy of Sciences, Vol. 551, 1988, p. 270-272.

Research output: Contribution to journalArticle

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AU - Silvestrini, B.

AU - Caputo, A.

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