Lonidamine-induced membrane permeability and the effect of adriamycin on the energy metabolism of Ehrlich ascites tumor cells

A. Floridi, A. Bagnato, C. Bianchi, M. Fanciulli, B. Silvestrini, A. Caputo

Research output: Contribution to journalArticlepeer-review

Abstract

It has been demonstrated that lonidamine (LND) potentiates the effect of adriamycin (ADM) by increasing membrane permeability of Ehrlich ascites tumor cells, thus allowing low ADM concentration (18 μM) to interfere also with oxidative metabolism. In order to establish whether the enhanced ADM susceptibility of LND-treated cells might be ascribed to a modified mitochondrial permeability, the effect of LND on cytochrome c oxygen reductase, a marker of the extent of outer mitochondrial membrane permeabilization, was evaluated.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume551
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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