It has been demonstrated that lonidamine (LND) potentiates the effect of adriamycin (ADM) by increasing membrane permeability of Ehrlich ascites tumor cells, thus allowing low ADM concentration (18 μM) to interfere also with oxidative metabolism. In order to establish whether the enhanced ADM susceptibility of LND-treated cells might be ascribed to a modified mitochondrial permeability, the effect of LND on cytochrome c oxygen reductase, a marker of the extent of outer mitochondrial membrane permeabilization, was evaluated.
|Number of pages||3|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)