Looking for the compass in a case of developmental topographical disorientation: A behavioral and neuroimaging study

Liana Palermo, Laura Piccardi, Filippo Bianchini, Federico Nemmi, Vincenzo Giorgio, Chiara Incoccia, Umberto Sabatini, Cecilia Guariglia

Research output: Contribution to journalArticle

Abstract

Developmental topographical disorientation (DTD) is the presence of navigational deficits in the context of normal intellectual ability and in the absence of any perinatal, neurological, or psychiatric disorder. As only three cases of DTD have been fully described thus far, we are still unable to draw definitive conclusions about its nature and relationship with other visuospatial competencies, such as mental rotation. The case of Mr. L.A., a 38-year-old man with no history of neurological or psychiatric disorders, sheds some light on these open questions. A neuropsychological assessment including IQ, memory, visuospatial, visuoconstructive, and navigational tests showed that Mr. L.A. has pure navigational deficits affecting both route knowledge and cognitive map processing. Unlike previously described cases of DTD, Mr. L.A. was not affected by any other visuospatial or visuoconstructive deficits. In a functional magnetic resonance imaging (fMRI) task involving the recall of route knowledge, Mr. L.A. showed activation in the occipital areas, involved in low-level perceptual analysis of the stimuli, and showed no activation in the areas activated in controls with regard to route knowledge. The present case suggests that different types of DTD exist, which are characterized by different navigational difficulties and anomalous/lacking functional brain activities in specific navigational networks.

Original languageEnglish
Pages (from-to)464-481
Number of pages18
JournalJournal of Clinical and Experimental Neuropsychology
Volume36
Issue number5
DOIs
Publication statusPublished - May 28 2014

Keywords

  • Cognitive map
  • Developmental disorders
  • Functional magnetic resonance imaging
  • Human navigation
  • Mental rotation
  • Spatial memory
  • Topographical disorientation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

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