Looking toward predicting functional recovery in disorders of consciousness

can sensorimotor integration help us?

Luana Billeri, Antonino Naro, Antonino Leo, Bruno Galletti, Provvidenza Tomasello, Alfredo Manuli, Veronica Andronaco, Paola Lauria, Alessia Bramanti, Rocco Salvatore Calabrò

Research output: Contribution to journalArticle

Abstract

PRIMARY OBJECTIVE: Only a few objective prognostic markers are available for patients with disorders of consciousness (DoC). We assessed whether the magnitude of short-latency afferent inhibition (SAI) might be a useful predictor of responsiveness recovery and functional outcome in patients with DoC.

RESEARCH DESIGN: We enrolled 40 patients with prolonged Minimally Conscious State (MCS) and Unresponsive Wakefulness Syndrome (UWS) in a longitudinal, observational study.

METHODS AND PROCEDURES: Clinical features (including Coma Recovery Scale-Revised, CRS-R, and Glasgow Outcome Scale, GOS) and SAI were collected at the study entry and after 18 months from study inclusion, to assess a correlation between SAI and the clinical outcome.

MAIN OUTCOMES AND RESULTS: At the follow-up, 19 patients remained in their baseline condition, whereas 7 UWS evolved into MCS or emerged-from-MCS (EMCS), eight MCS evolved into EMCS, and two MCS- evolved into MCS+. Two UWS and one MCS+ died for cardiopulmonary complications. The patients who showed the highest GOS, the highest CRS-R and the lowest SAI strength at study entry, improved at the follow-up.

CONCLUSIONS: Our findings suggest that an objective and simple neurophysiologic measure as SAI strength could provide useful information to predict the outcome and the behavioral responsiveness of patients with DoC.

Original languageEnglish
Pages (from-to)364-369
Number of pages6
JournalBrain Injury
Volume33
Issue number3
DOIs
Publication statusPublished - 2019

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Consciousness Disorders
Persistent Vegetative State
Wakefulness
Glasgow Outcome Scale
Coma
Observational Studies
Longitudinal Studies
Inhibition (Psychology)

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Looking toward predicting functional recovery in disorders of consciousness : can sensorimotor integration help us? / Billeri, Luana; Naro, Antonino; Leo, Antonino; Galletti, Bruno; Tomasello, Provvidenza; Manuli, Alfredo; Andronaco, Veronica; Lauria, Paola; Bramanti, Alessia; Calabrò, Rocco Salvatore.

In: Brain Injury, Vol. 33, No. 3, 2019, p. 364-369.

Research output: Contribution to journalArticle

Billeri, Luana ; Naro, Antonino ; Leo, Antonino ; Galletti, Bruno ; Tomasello, Provvidenza ; Manuli, Alfredo ; Andronaco, Veronica ; Lauria, Paola ; Bramanti, Alessia ; Calabrò, Rocco Salvatore. / Looking toward predicting functional recovery in disorders of consciousness : can sensorimotor integration help us?. In: Brain Injury. 2019 ; Vol. 33, No. 3. pp. 364-369.
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AU - Manuli, Alfredo

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AU - Lauria, Paola

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