Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome

Cristina Cristofoletti; Antonella Bresin; Elisabetta Caprini; Giandomenico Russo; Maria Grazia Narducci

doi:10.1080/15384101.2019.1617007

Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome

Cristina Cristofoletti, Antonella Bresin, Elisabetta Caprini, Giandomenico Russo, Maria Grazia Narducci

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present evidence also of the involvement of B-arrestin a downstream regulator of CXCR4, that is depleted and downregulated as well as a potential functional role for this depletion.

Original language	English
Pages (from-to)	1292-1294
Number of pages	3
Journal	Cell Cycle
Volume	18
Issue number	11
DOIs	https://doi.org/10.1080/15384101.2019.1617007
Publication status	Published - Jun 2019

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title = "Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome",

abstract = "Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present evidence also of the involvement of B-arrestin a downstream regulator of CXCR4, that is depleted and downregulated as well as a potential functional role for this depletion.",

author = "Cristina Cristofoletti and Antonella Bresin and Elisabetta Caprini and Giandomenico Russo and Narducci, {Maria Grazia}",

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AU - Cristofoletti, Cristina

AU - Bresin, Antonella

AU - Caprini, Elisabetta

AU - Russo, Giandomenico

AU - Narducci, Maria Grazia

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AB - Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present evidence also of the involvement of B-arrestin a downstream regulator of CXCR4, that is depleted and downregulated as well as a potential functional role for this depletion.

U2 - 10.1080/15384101.2019.1617007

DO - 10.1080/15384101.2019.1617007

M3 - Article

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VL - 18

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JO - Cell Cycle

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SN - 1538-4101

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