Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma

Annalisa Pezzolo, Simona Coco, Alessandro Raso, Federica Parodi, Angela Pistorio, Francesca Valdora, Valeria Capra, Massimo Zollo, Simona Aschero, Eleonora Basso, Armando Cama, Paolo Nozza, Claudio Gambini, Giuseppe Cinalli, Maria Luisa Garrè, Achille Iolascon, Vito Pistoia, Gian Paolo Tonini

Research output: Contribution to journalArticle

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1-q26.3 loss combined with 17q24.3-q25.3 gain and/or 7q34-q36.3 gain in tumors predicted poor patient's survival. A minimal deleted region of 14.12. cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations.

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalCancer Letters
Volume308
Issue number2
DOIs
Publication statusPublished - Sep 28 2011

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Medulloblastoma
Pediatrics
Prometaphase
Comparative Genomic Hybridization
Brain Neoplasms
Chromosomes
Survival
Neoplasms

Keywords

  • CGH
  • Chromosomal imbalances
  • FISH
  • LOH
  • Medulloblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. / Pezzolo, Annalisa; Coco, Simona; Raso, Alessandro; Parodi, Federica; Pistorio, Angela; Valdora, Francesca; Capra, Valeria; Zollo, Massimo; Aschero, Simona; Basso, Eleonora; Cama, Armando; Nozza, Paolo; Gambini, Claudio; Cinalli, Giuseppe; Garrè, Maria Luisa; Iolascon, Achille; Pistoia, Vito; Tonini, Gian Paolo.

In: Cancer Letters, Vol. 308, No. 2, 28.09.2011, p. 215-224.

Research output: Contribution to journalArticle

Pezzolo, Annalisa ; Coco, Simona ; Raso, Alessandro ; Parodi, Federica ; Pistorio, Angela ; Valdora, Francesca ; Capra, Valeria ; Zollo, Massimo ; Aschero, Simona ; Basso, Eleonora ; Cama, Armando ; Nozza, Paolo ; Gambini, Claudio ; Cinalli, Giuseppe ; Garrè, Maria Luisa ; Iolascon, Achille ; Pistoia, Vito ; Tonini, Gian Paolo. / Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. In: Cancer Letters. 2011 ; Vol. 308, No. 2. pp. 215-224.
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AU - Coco, Simona

AU - Raso, Alessandro

AU - Parodi, Federica

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AU - Valdora, Francesca

AU - Capra, Valeria

AU - Zollo, Massimo

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AU - Basso, Eleonora

AU - Cama, Armando

AU - Nozza, Paolo

AU - Gambini, Claudio

AU - Cinalli, Giuseppe

AU - Garrè, Maria Luisa

AU - Iolascon, Achille

AU - Pistoia, Vito

AU - Tonini, Gian Paolo

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AB - Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1-q26.3 loss combined with 17q24.3-q25.3 gain and/or 7q34-q36.3 gain in tumors predicted poor patient's survival. A minimal deleted region of 14.12. cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations.

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KW - Chromosomal imbalances

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KW - LOH

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