Abstract
We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (
| Original language | English |
|---|---|
| Pages (from-to) | 1024-1028 |
| Number of pages | 5 |
| Journal | Haematologica |
| Volume | 94 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2009 |
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Keywords
- arrayCGH
- Chromosomal abnormality
- Plasma cell
- Progression
- Smouldering multiple myeloma
ASJC Scopus subject areas
- Hematology
Cite this
Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. / Chiecchio, Laura; Dagrada, Gian Paolo; Protheroe, Rebecca K M; Stockley, David M.; Smith, Alastair G.; Orchard, Kim H.; Cross, Nicholas C P; Harrison, Christine J.; Ross, Fiona M.
In: Haematologica, Vol. 94, No. 7, 07.2009, p. 1024-1028.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma
T2 - Sequential analysis of a single case
AU - Chiecchio, Laura
AU - Dagrada, Gian Paolo
AU - Protheroe, Rebecca K M
AU - Stockley, David M.
AU - Smith, Alastair G.
AU - Orchard, Kim H.
AU - Cross, Nicholas C P
AU - Harrison, Christine J.
AU - Ross, Fiona M.
PY - 2009/7
Y1 - 2009/7
N2 - We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (
AB - We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (
KW - arrayCGH
KW - Chromosomal abnormality
KW - Plasma cell
KW - Progression
KW - Smouldering multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=67650745974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650745974&partnerID=8YFLogxK
U2 - 10.3324/haematol.2008.004440
DO - 10.3324/haematol.2008.004440
M3 - Article
C2 - 19454499
AN - SCOPUS:67650745974
VL - 94
SP - 1024
EP - 1028
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 7
ER -