Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio, Gian Paolo Dagrada, Rebecca K M Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C P Cross, Christine J. Harrison, Fiona M. Ross

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (

Original languageEnglish
Pages (from-to)1024-1028
Number of pages5
JournalHaematologica
Volume94
Issue number7
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Plasma Cells
Chromosomes, Human, Pair 13
Comparative Genomic Hybridization
Population

Keywords

  • arrayCGH
  • Chromosomal abnormality
  • Plasma cell
  • Progression
  • Smouldering multiple myeloma

ASJC Scopus subject areas

  • Hematology

Cite this

Chiecchio, L., Dagrada, G. P., Protheroe, R. K. M., Stockley, D. M., Smith, A. G., Orchard, K. H., ... Ross, F. M. (2009). Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case. Haematologica, 94(7), 1024-1028. https://doi.org/10.3324/haematol.2008.004440

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. / Chiecchio, Laura; Dagrada, Gian Paolo; Protheroe, Rebecca K M; Stockley, David M.; Smith, Alastair G.; Orchard, Kim H.; Cross, Nicholas C P; Harrison, Christine J.; Ross, Fiona M.

In: Haematologica, Vol. 94, No. 7, 07.2009, p. 1024-1028.

Research output: Contribution to journalArticle

Chiecchio, L, Dagrada, GP, Protheroe, RKM, Stockley, DM, Smith, AG, Orchard, KH, Cross, NCP, Harrison, CJ & Ross, FM 2009, 'Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case', Haematologica, vol. 94, no. 7, pp. 1024-1028. https://doi.org/10.3324/haematol.2008.004440
Chiecchio, Laura ; Dagrada, Gian Paolo ; Protheroe, Rebecca K M ; Stockley, David M. ; Smith, Alastair G. ; Orchard, Kim H. ; Cross, Nicholas C P ; Harrison, Christine J. ; Ross, Fiona M. / Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. In: Haematologica. 2009 ; Vol. 94, No. 7. pp. 1024-1028.
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