Abstract
We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (
Original language | English |
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Pages (from-to) | 1024-1028 |
Number of pages | 5 |
Journal | Haematologica |
Volume | 94 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2009 |
Keywords
- arrayCGH
- Chromosomal abnormality
- Plasma cell
- Progression
- Smouldering multiple myeloma
ASJC Scopus subject areas
- Hematology