Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio; Gian Paolo Dagrada; Rebecca K M Protheroe; David M. Stockley; Alastair G. Smith; Kim H. Orchard; Nicholas C P Cross; Christine J. Harrison; Fiona M. Ross

doi:10.3324/haematol.2008.004440

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio, Gian Paolo Dagrada, Rebecca K M Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C P Cross, Christine J. Harrison, Fiona M. Ross

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (

Original language	English
Pages (from-to)	1024-1028
Number of pages	5
Journal	Haematologica
Volume	94
Issue number	7
DOIs	https://doi.org/10.3324/haematol.2008.004440
Publication status	Published - Jul 2009

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Keywords

arrayCGH
Chromosomal abnormality
Plasma cell
Progression
Smouldering multiple myeloma

ASJC Scopus subject areas

Hematology

Cite this

Chiecchio, L., Dagrada, G. P., Protheroe, R. K. M., Stockley, D. M., Smith, A. G., Orchard, K. H., Cross, N. C. P., Harrison, C. J., & Ross, F. M. (2009). Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case. Haematologica, 94(7), 1024-1028. https://doi.org/10.3324/haematol.2008.004440

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. / Chiecchio, Laura; Dagrada, Gian Paolo; Protheroe, Rebecca K M; Stockley, David M.; Smith, Alastair G.; Orchard, Kim H.; Cross, Nicholas C P; Harrison, Christine J.; Ross, Fiona M.

In: Haematologica, Vol. 94, No. 7, 07.2009, p. 1024-1028.

Research output: Contribution to journal › Article

Chiecchio, Laura ; Dagrada, Gian Paolo ; Protheroe, Rebecca K M ; Stockley, David M. ; Smith, Alastair G. ; Orchard, Kim H. ; Cross, Nicholas C P ; Harrison, Christine J. ; Ross, Fiona M. / Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. In: Haematologica. 2009 ; Vol. 94, No. 7. pp. 1024-1028.

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10.3324/haematol.2008.004440