Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio; Gian Paolo Dagrada; Rebecca K M Protheroe; David M. Stockley; Alastair G. Smith; Kim H. Orchard; Nicholas C P Cross; Christine J. Harrison; Fiona M. Ross

doi:10.3324/haematol.2008.004440

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio, Gian Paolo Dagrada, Rebecca K M Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C P Cross, Christine J. Harrison, Fiona M. Ross

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (

Original language	English
Pages (from-to)	1024-1028
Number of pages	5
Journal	Haematologica
Volume	94
Issue number	7
DOIs	https://doi.org/10.3324/haematol.2008.004440
Publication status	Published - Jul 2009

Keywords

arrayCGH
Chromosomal abnormality
Plasma cell
Progression
Smouldering multiple myeloma

ASJC Scopus subject areas

Hematology

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10.3324/haematol.2008.004440

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Chiecchio, L., Dagrada, G. P., Protheroe, R. K. M., Stockley, D. M., Smith, A. G., Orchard, K. H., Cross, N. C. P., Harrison, C. J., & Ross, F. M. (2009). Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case. Haematologica, 94(7), 1024-1028. https://doi.org/10.3324/haematol.2008.004440

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. / Chiecchio, Laura; Dagrada, Gian Paolo; Protheroe, Rebecca K M; Stockley, David M.; Smith, Alastair G.; Orchard, Kim H.; Cross, Nicholas C P; Harrison, Christine J.; Ross, Fiona M.

In: Haematologica, Vol. 94, No. 7, 07.2009, p. 1024-1028.

Research output: Contribution to journal › Article › peer-review

Chiecchio, Laura ; Dagrada, Gian Paolo ; Protheroe, Rebecca K M ; Stockley, David M. ; Smith, Alastair G. ; Orchard, Kim H. ; Cross, Nicholas C P ; Harrison, Christine J. ; Ross, Fiona M. / Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma : Sequential analysis of a single case. In: Haematologica. 2009 ; Vol. 94, No. 7. pp. 1024-1028.

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Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Abstract

Keywords

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