Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case

Laura Chiecchio, Gian Paolo Dagrada, Rebecca K M Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C P Cross, Christine J. Harrison, Fiona M. Ross

Research output: Contribution to journalArticle

Abstract

We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (

Original languageEnglish
Pages (from-to)1024-1028
Number of pages5
JournalHaematologica
Volume94
Issue number7
DOIs
Publication statusPublished - Jul 2009

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Keywords

  • arrayCGH
  • Chromosomal abnormality
  • Plasma cell
  • Progression
  • Smouldering multiple myeloma

ASJC Scopus subject areas

  • Hematology

Cite this

Chiecchio, L., Dagrada, G. P., Protheroe, R. K. M., Stockley, D. M., Smith, A. G., Orchard, K. H., Cross, N. C. P., Harrison, C. J., & Ross, F. M. (2009). Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case. Haematologica, 94(7), 1024-1028. https://doi.org/10.3324/haematol.2008.004440