Loss of heterozigosity for 1p chromosome in neuroblastoma

C. Valenti, D. Di Martino, B. De Bernardi, A. Garaventa, F. Bottini, G. P. Tonini

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroblastoma is characterized by non-random chromosome 1p deletion. About 70% of human neuroblastomas in advanced stages show loss of the short arm of chromosome 1. Moreover, the remaining neuroblastomas can have molecular deletion that are not detected by cytogenetic analysis. We studied loss of heterozigosity (LOH) on chromosome 1 in 26 neuroblastoma tissues belonging to patients in different stages of disease employing probes derived from microdissection and microcloning of the short arm of chromosome 1. LOH was found both in patients in stage 1 and in stage 4. Patients in stage 4 show consistent deletion at locus D1S94 corresponding to the chromosomal region 1p36.11-1p36.12. In this region could be located the putative neuroblastoma supressor gene. Combined analysis of LOH and MYCN gene amplification does not show relation between these two molecular abnormalities.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Volume5
Issue number4-6
Publication statusPublished - 1993

Keywords

  • Chromosome 1
  • Loss-of-heterozigosity
  • MYCN oncogene
  • Neuroblastoma

ASJC Scopus subject areas

  • Clinical Biochemistry

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