Abstract
Frequent loss of a specific chromosomic region in cancers is often associated with inactivation of a tumor-suppressor gene. The long arm of chromosome 10 is deleted in several types of tumor, among them squamous-cell carcinomas of the head and neck (HNSCC). To determine the role of 10q deletions in the tumorigenesis of the upper respiratory tract, 47 HNSCCs were examined for loss of heterozygosity (LOH) at 10q: 43% of the cases analyzed showed LOH at 10q, and 2 distinct hot spots of deletion were identified, at 10q22-23 and 10q25-26. The possible involvement of pTEN/MMAC1, a tumor- suppressor gene mapped at 10q23, was also evaluated. No mutation, homozygous deletion or loss of expression of pTEN/MMAC1 was detected, indicating that inactivation of this gene plays a minor role in HNSCC development. Interestingly, the frequency of deletion at 10q was greater in invasive carcinoma than in adjacent carcinoma in situ, and a significant association between LOH and poor prognosis was observed. Taken together, our results suggest the presence in the long arm of chromosome 10 of (a) tumor- suppressor gene(s) other than pTEN/MMAC1 and presumably involved in the malignant progression of tumors of the upper respiratory tract.
| Original language | English |
|---|---|
| Pages (from-to) | 432-436 |
| Number of pages | 5 |
| Journal | International Journal of Cancer |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis. / Gasparotto, Daniela; Vukosavljevic, Tamara; Piccinin, Sara; Barzan, Luigi; Sulfaro, Sandro; Armellin, Michela; Boiocchi, Mauro; Maestro, Roberta.
In: International Journal of Cancer, Vol. 84, No. 4, 1999, p. 432-436.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis
AU - Gasparotto, Daniela
AU - Vukosavljevic, Tamara
AU - Piccinin, Sara
AU - Barzan, Luigi
AU - Sulfaro, Sandro
AU - Armellin, Michela
AU - Boiocchi, Mauro
AU - Maestro, Roberta
PY - 1999
Y1 - 1999
N2 - Frequent loss of a specific chromosomic region in cancers is often associated with inactivation of a tumor-suppressor gene. The long arm of chromosome 10 is deleted in several types of tumor, among them squamous-cell carcinomas of the head and neck (HNSCC). To determine the role of 10q deletions in the tumorigenesis of the upper respiratory tract, 47 HNSCCs were examined for loss of heterozygosity (LOH) at 10q: 43% of the cases analyzed showed LOH at 10q, and 2 distinct hot spots of deletion were identified, at 10q22-23 and 10q25-26. The possible involvement of pTEN/MMAC1, a tumor- suppressor gene mapped at 10q23, was also evaluated. No mutation, homozygous deletion or loss of expression of pTEN/MMAC1 was detected, indicating that inactivation of this gene plays a minor role in HNSCC development. Interestingly, the frequency of deletion at 10q was greater in invasive carcinoma than in adjacent carcinoma in situ, and a significant association between LOH and poor prognosis was observed. Taken together, our results suggest the presence in the long arm of chromosome 10 of (a) tumor- suppressor gene(s) other than pTEN/MMAC1 and presumably involved in the malignant progression of tumors of the upper respiratory tract.
AB - Frequent loss of a specific chromosomic region in cancers is often associated with inactivation of a tumor-suppressor gene. The long arm of chromosome 10 is deleted in several types of tumor, among them squamous-cell carcinomas of the head and neck (HNSCC). To determine the role of 10q deletions in the tumorigenesis of the upper respiratory tract, 47 HNSCCs were examined for loss of heterozygosity (LOH) at 10q: 43% of the cases analyzed showed LOH at 10q, and 2 distinct hot spots of deletion were identified, at 10q22-23 and 10q25-26. The possible involvement of pTEN/MMAC1, a tumor- suppressor gene mapped at 10q23, was also evaluated. No mutation, homozygous deletion or loss of expression of pTEN/MMAC1 was detected, indicating that inactivation of this gene plays a minor role in HNSCC development. Interestingly, the frequency of deletion at 10q was greater in invasive carcinoma than in adjacent carcinoma in situ, and a significant association between LOH and poor prognosis was observed. Taken together, our results suggest the presence in the long arm of chromosome 10 of (a) tumor- suppressor gene(s) other than pTEN/MMAC1 and presumably involved in the malignant progression of tumors of the upper respiratory tract.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032794762&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0215(19990820)84:4<432::AID-IJC18>3.0.CO;2-#
DO - 10.1002/(SICI)1097-0215(19990820)84:4<432::AID-IJC18>3.0.CO;2-#
M3 - Article
VL - 84
SP - 432
EP - 436
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 4
ER -