Loss of heterozygosity for chromosome 1p in familial neuroblastoma

G. P. Tonini, C. Lo Cunsolo, R. Cusano, A. Iolascon, M. Dagnino, M. Conte, C. Milanaccio, B. De Bernardi, K. Mazzocco, P. Scaruffi

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Abstract

Loss of heterozygosity (LOH) and deletion of chromosome 1p are very often found in sporadic neuroblastoma. Nevertheless, very few data are available concerning 1p LOH in familial neuroblastoma. Families with recurrent neuroblastoma are rare and analysis of chromosome 1p in these families might give useful information for identifying the putative neuroblastoma suppressor gene. We used combined cytogenetic and molecular techniques to study 1p LOH in two neuroblastoma families. Family M has 2 out of 3 children with neuroblastoma and family C has 2 children, 1 of whom has neuroblastoma and type 1 neurofibromatosis (NF1). All patients of both families showed tumour cells with chromosome 1p deletion (1pdel), but only the patient from family C also had MYCN gene amplification. In all cases the deleted chromosome 1 was of maternal origin.

Original languageEnglish
Pages (from-to)1953-1956
Number of pages4
JournalEuropean Journal of Cancer
Volume33
Issue number12
DOIs
Publication statusPublished - Oct 1997

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Keywords

  • Chromosome 1p
  • Deletion
  • Familial neuroblastoma
  • MYCN amplification

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Tonini, G. P., Lo Cunsolo, C., Cusano, R., Iolascon, A., Dagnino, M., Conte, M., Milanaccio, C., De Bernardi, B., Mazzocco, K., & Scaruffi, P. (1997). Loss of heterozygosity for chromosome 1p in familial neuroblastoma. European Journal of Cancer, 33(12), 1953-1956. https://doi.org/10.1016/S0959-8049(97)00288-8