Loss of heterozygosity in human germinal tumors

P. Radice, M. A. Pierotti, S. Lacerenza, P. Mondini, M. T. Radice, S. Pilotti, G. Della Porta

Research output: Contribution to journalArticlepeer-review


The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin. These results suggest that different genetic mechanisms (chromosomal deletions or meiotic segregation) that unmask putative recessive mutations are involved in the onset of germinal tumors.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalCytogenetics and Cell Genetics
Issue number1-2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Genetics
  • Cell Biology


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