Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons

Alessandra Folci, Lisa Mapelli, Jenny Sassone, Francesca Prestori, Egidio D'Angelo, Silvia Bassani, Maria Passafaro

Research output: Contribution to journalArticlepeer-review

Abstract

Heterogeneous nuclear ribonucleoproteinK(hnRNP K) is an RNA-binding protein implicated inRNAmetabolism. Here, we investigated the role of hnRNP K in synapse function. We demonstrated that hnRNP K regulates dendritic spine density and long-term potentiation (LTP) in cultured hippocampal neurons from embryonic rats. LTP requires the extracellular signal-regulated kinase (ERK)1/2-mediated phosphorylation and cytoplasmic accumulation of hnRNP K. Moreover, hnRNP K knockdown prevents ERK cascade activation and GluA1-S845 phosphorylation and surface delivery, which are essential steps for LTP. These findings establish hnRNP K as a new critical regulator of synaptic transmission and plasticity in hippocampal neurons.

Original languageEnglish
Pages (from-to)9088-9095
Number of pages8
JournalJournal of Neuroscience
Volume34
Issue number27
DOIs
Publication statusPublished - 2014

Keywords

  • Dendritic spines
  • HnRNP K
  • LTP
  • Neurons
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

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