Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Edda Battaglia, Gabrio Bassotti, Graziella Bellone, Luca Dughera, Anna Maria Serra, Luigi Chiusa, Alessandro Repici, Pierroberto Mioli, Giorgio Emanuelli

Research output: Contribution to journalArticle

Abstract

Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

Original languageEnglish
Pages (from-to)6172-6177
Number of pages6
JournalWorld Journal of Gastroenterology
Volume12
Issue number38
Publication statusPublished - Oct 14 2006

Keywords

  • C-kit
  • Gastroparesis
  • Interstitial cells of Cajal
  • Stem cell factor

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Battaglia, E., Bassotti, G., Bellone, G., Dughera, L., Serra, A. M., Chiusa, L., Repici, A., Mioli, P., & Emanuelli, G. (2006). Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis. World Journal of Gastroenterology, 12(38), 6172-6177.