Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Edda Battaglia; Gabrio Bassotti; Graziella Bellone; Luca Dughera; Anna Maria Serra; Luigi Chiusa; Alessandro Repici; Pierroberto Mioli; Giorgio Emanuelli

Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Edda Battaglia, Gabrio Bassotti, Graziella Bellone, Luca Dughera, Anna Maria Serra, Luigi Chiusa, Alessandro Repici, Pierroberto Mioli, Giorgio Emanuelli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

Original language	English
Pages (from-to)	6172-6177
Number of pages	6
Journal	World Journal of Gastroenterology
Volume	12
Issue number	38
Publication status	Published - Oct 14 2006

Keywords

C-kit
Gastroparesis
Interstitial cells of Cajal
Stem cell factor

ASJC Scopus subject areas

Gastroenterology

Cite this

Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis. / Battaglia, Edda; Bassotti, Gabrio; Bellone, Graziella; Dughera, Luca; Serra, Anna Maria; Chiusa, Luigi; Repici, Alessandro; Mioli, Pierroberto; Emanuelli, Giorgio.

In: World Journal of Gastroenterology, Vol. 12, No. 38, 14.10.2006, p. 6172-6177.

Research output: Contribution to journal › Article › peer-review

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abstract = "Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.",

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AU - Battaglia, Edda

AU - Bassotti, Gabrio

AU - Bellone, Graziella

AU - Dughera, Luca

AU - Serra, Anna Maria

AU - Chiusa, Luigi

AU - Repici, Alessandro

AU - Mioli, Pierroberto

AU - Emanuelli, Giorgio

PY - 2006/10/14

Y1 - 2006/10/14

N2 - Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

AB - Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

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Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Abstract

Keywords

ASJC Scopus subject areas

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