Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Edda Battaglia; Gabrio Bassotti; Graziella Bellone; Luca Dughera; Anna Maria Serra; Luigi Chiusa; Alessandro Repici; Pierroberto Mioli; Giorgio Emanuelli

Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Edda Battaglia, Gabrio Bassotti, Graziella Bellone, Luca Dughera, Anna Maria Serra, Luigi Chiusa, Alessandro Repici, Pierroberto Mioli, Giorgio Emanuelli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

Original language	English
Pages (from-to)	6172-6177
Number of pages	6
Journal	World Journal of Gastroenterology
Volume	12
Issue number	38
Publication status	Published - Oct 14 2006

Keywords

C-kit
Gastroparesis
Interstitial cells of Cajal
Stem cell factor

ASJC Scopus subject areas

Gastroenterology

Cite this

@article{e9db19fbbbb14c259528b3a5e92372bb,

title = "Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis",

abstract = "Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.",

keywords = "C-kit, Gastroparesis, Interstitial cells of Cajal, Stem cell factor",

author = "Edda Battaglia and Gabrio Bassotti and Graziella Bellone and Luca Dughera and Serra, {Anna Maria} and Luigi Chiusa and Alessandro Repici and Pierroberto Mioli and Giorgio Emanuelli",

year = "2006",

month = oct,

day = "14",

language = "English",

volume = "12",

pages = "6172--6177",

journal = "World Journal of Gastroenterology",

issn = "1007-9327",

publisher = "WJG Press",

number = "38",

}

TY - JOUR

T1 - Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

AU - Battaglia, Edda

AU - Bassotti, Gabrio

AU - Bellone, Graziella

AU - Dughera, Luca

AU - Serra, Anna Maria

AU - Chiusa, Luigi

AU - Repici, Alessandro

AU - Mioli, Pierroberto

AU - Emanuelli, Giorgio

PY - 2006/10/14

Y1 - 2006/10/14

N2 - Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

AB - Aim: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). Methods: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. Results: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. Conclusion: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

KW - C-kit

KW - Gastroparesis

KW - Interstitial cells of Cajal

KW - Stem cell factor

UR - http://www.scopus.com/inward/record.url?scp=33750618369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750618369&partnerID=8YFLogxK

M3 - Article

C2 - 17036390

AN - SCOPUS:33750618369

VL - 12

SP - 6172

EP - 6177

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 38

ER -

Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this