Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

Kehmia Titanji, Angelo De Milito, Alberto Cagigi, Rigmor Thorstensson, Sven Grützmeier, Ann Atlas, Bo Hejdeman, Frank P. Kroon, Lucia Lopalco, Anna Nilsson, Francesca Chiodi

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients.We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4+ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initiated early in infection. This may have important consequences for the response of HIV-infected patients to immunizations.

Original languageEnglish
Pages (from-to)1580-1587
Number of pages8
JournalBlood
Volume108
Issue number5
DOIs
Publication statusPublished - Sep 1 2006

Fingerprint

Long-Term Memory
Memory Disorders
HIV Infections
HIV-1
B-Lymphocytes
Cells
Data storage equipment
Measles
Antigens
Disease Progression
Antibodies
Immunoglobulin G
Infection
Defects
Antibody-Producing Cells
Blood
CD4 Lymphocyte Count
Streptococcus pneumoniae
Immunization
Plasmas

ASJC Scopus subject areas

  • Hematology

Cite this

Titanji, K., De Milito, A., Cagigi, A., Thorstensson, R., Grützmeier, S., Atlas, A., ... Chiodi, F. (2006). Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood, 108(5), 1580-1587. https://doi.org/10.1182/blood-2005-11-013383

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. / Titanji, Kehmia; De Milito, Angelo; Cagigi, Alberto; Thorstensson, Rigmor; Grützmeier, Sven; Atlas, Ann; Hejdeman, Bo; Kroon, Frank P.; Lopalco, Lucia; Nilsson, Anna; Chiodi, Francesca.

In: Blood, Vol. 108, No. 5, 01.09.2006, p. 1580-1587.

Research output: Contribution to journalArticle

Titanji, K, De Milito, A, Cagigi, A, Thorstensson, R, Grützmeier, S, Atlas, A, Hejdeman, B, Kroon, FP, Lopalco, L, Nilsson, A & Chiodi, F 2006, 'Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection', Blood, vol. 108, no. 5, pp. 1580-1587. https://doi.org/10.1182/blood-2005-11-013383
Titanji K, De Milito A, Cagigi A, Thorstensson R, Grützmeier S, Atlas A et al. Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood. 2006 Sep 1;108(5):1580-1587. https://doi.org/10.1182/blood-2005-11-013383
Titanji, Kehmia ; De Milito, Angelo ; Cagigi, Alberto ; Thorstensson, Rigmor ; Grützmeier, Sven ; Atlas, Ann ; Hejdeman, Bo ; Kroon, Frank P. ; Lopalco, Lucia ; Nilsson, Anna ; Chiodi, Francesca. / Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. In: Blood. 2006 ; Vol. 108, No. 5. pp. 1580-1587.
@article{28a5a8db484647e1a76f9a845e0cf56c,
title = "Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection",
abstract = "Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients.We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4+ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initiated early in infection. This may have important consequences for the response of HIV-infected patients to immunizations.",
author = "Kehmia Titanji and {De Milito}, Angelo and Alberto Cagigi and Rigmor Thorstensson and Sven Gr{\"u}tzmeier and Ann Atlas and Bo Hejdeman and Kroon, {Frank P.} and Lucia Lopalco and Anna Nilsson and Francesca Chiodi",
year = "2006",
month = "9",
day = "1",
doi = "10.1182/blood-2005-11-013383",
language = "English",
volume = "108",
pages = "1580--1587",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "5",

}

TY - JOUR

T1 - Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

AU - Titanji, Kehmia

AU - De Milito, Angelo

AU - Cagigi, Alberto

AU - Thorstensson, Rigmor

AU - Grützmeier, Sven

AU - Atlas, Ann

AU - Hejdeman, Bo

AU - Kroon, Frank P.

AU - Lopalco, Lucia

AU - Nilsson, Anna

AU - Chiodi, Francesca

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients.We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4+ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initiated early in infection. This may have important consequences for the response of HIV-infected patients to immunizations.

AB - Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients.We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4+ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initiated early in infection. This may have important consequences for the response of HIV-infected patients to immunizations.

UR - http://www.scopus.com/inward/record.url?scp=33748176405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748176405&partnerID=8YFLogxK

U2 - 10.1182/blood-2005-11-013383

DO - 10.1182/blood-2005-11-013383

M3 - Article

C2 - 16645169

AN - SCOPUS:33748176405

VL - 108

SP - 1580

EP - 1587

JO - Blood

JF - Blood

SN - 0006-4971

IS - 5

ER -