Abstract
Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Angiogenesis is a promising target for this tumor type, however clinical trials with the use of anti-angiogenic drugs have so far not met expectations. Therefore, it is important to better characterize the expression of molecules whose expression levels may impact on the efficacy of the treatments. In this study the characteristics of the gastric tumor associated blood vessels were first assessed by endomicroscopy. Next, we analyzed the expression of Multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules play important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. All the molecules were highly expressed in the normal mucosa whereas in a number of patients their expression was altered. We consider that better characterizing the gastric tumor microenvironment and the quality of the vasculature may achieve effective patient tailored therapies.
| Original language | English |
|---|---|
| Article number | 3983 |
| Journal | International Journal of Molecular Sciences |
| Volume | 19 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2018 |
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Keywords
- Angiogenesis
- Endomicroscopy
- Extracellular matrix
- Gastric cancer
- Lymphangiogenesis
- Tumor microenvironment
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
Loss of multimerin-2 and EMILIN-2 expression in gastric cancer associate with altered angiogenesis. / Andreuzzi, Eva; Capuano, Alessandra; Pellicani, Rosanna; Poletto, Evelina; Doliana, Roberto; Maiero, Stefania; Fornasarig, Mara; Magris, Raffaella; Colombatti, Alfonso; Cannizzaro, Renato; Spessotto, Paola; Mongiat, Maurizio.
In: International Journal of Molecular Sciences, Vol. 19, No. 12, 3983, 01.12.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of multimerin-2 and EMILIN-2 expression in gastric cancer associate with altered angiogenesis
AU - Andreuzzi, Eva
AU - Capuano, Alessandra
AU - Pellicani, Rosanna
AU - Poletto, Evelina
AU - Doliana, Roberto
AU - Maiero, Stefania
AU - Fornasarig, Mara
AU - Magris, Raffaella
AU - Colombatti, Alfonso
AU - Cannizzaro, Renato
AU - Spessotto, Paola
AU - Mongiat, Maurizio
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Angiogenesis is a promising target for this tumor type, however clinical trials with the use of anti-angiogenic drugs have so far not met expectations. Therefore, it is important to better characterize the expression of molecules whose expression levels may impact on the efficacy of the treatments. In this study the characteristics of the gastric tumor associated blood vessels were first assessed by endomicroscopy. Next, we analyzed the expression of Multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules play important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. All the molecules were highly expressed in the normal mucosa whereas in a number of patients their expression was altered. We consider that better characterizing the gastric tumor microenvironment and the quality of the vasculature may achieve effective patient tailored therapies.
AB - Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Angiogenesis is a promising target for this tumor type, however clinical trials with the use of anti-angiogenic drugs have so far not met expectations. Therefore, it is important to better characterize the expression of molecules whose expression levels may impact on the efficacy of the treatments. In this study the characteristics of the gastric tumor associated blood vessels were first assessed by endomicroscopy. Next, we analyzed the expression of Multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules play important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. All the molecules were highly expressed in the normal mucosa whereas in a number of patients their expression was altered. We consider that better characterizing the gastric tumor microenvironment and the quality of the vasculature may achieve effective patient tailored therapies.
KW - Angiogenesis
KW - Endomicroscopy
KW - Extracellular matrix
KW - Gastric cancer
KW - Lymphangiogenesis
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85058271031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058271031&partnerID=8YFLogxK
U2 - 10.3390/ijms19123983
DO - 10.3390/ijms19123983
M3 - Article
C2 - 30544909
AN - SCOPUS:85058271031
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 12
M1 - 3983
ER -