Loss of muscle oxidative rapacity after an extreme endurance run

The Paris-Dakar foot-race

D. Hochli, T. Schneiter, G. Ferretti, H. Howald, H. Claassen, C. Moia, G. Atchou, M. Belleri, A. Veicsteinas, H. Hoppeler

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We measured changes in maximal oxygen uptake capacity (V̇O2max), ventilation, heart rate, plasma lactate and speed at the end of an incremental exercise test as a consequence of a relay foot race from Paris to Daltar in 6 subjects. Additionally, anthropometric measurements were taken and muscle biopsies from M. vastus lateralis were obtained before and after the race. The latter were analyzed with morphometric methods for fiber size, capillarity and muscle ultrastructural composition. Weight specific V̇O2max was significantly reduced from 62.4 to 60.5 ml/min . kg after the race while absolute V̇O2max and the other endurance related functional variables remained unchanged. Body fat, thigh cross-sectional area and thigh volume showed tendential reduction immediately after the race but regained pre-race values within a few days. Fiber size and capillarity were not affected by the race. Volume density of total mitochondria was significantly reduced from 6.98 to 4.89% of fiber volume. Both subsarcolemmal and interfibrillar mitochondria were significantly reduced by 59 and 21%, respectively. The volume density of satellite cell was increased about three-fold whereas the content of lipofuscin remained constant. It is concluded that extreme endurance events such as a multi-stage relay race may induce a considerable loss of oxidative capacity of skeletal muscle tissue.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalInternational Journal of Sports Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - 1995

Fingerprint

Paris
Foot
Muscles
Capillary Action
Thigh
Mitochondria
Lipofuscin
Quadriceps Muscle
Exercise Test
Ventilation
Adipose Tissue
Lactic Acid
Skeletal Muscle
Cell Count
Heart Rate
Oxygen
Biopsy
Weights and Measures

Keywords

  • Maximum O consumption
  • Mitochondria
  • Running
  • Training

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hochli, D., Schneiter, T., Ferretti, G., Howald, H., Claassen, H., Moia, C., ... Hoppeler, H. (1995). Loss of muscle oxidative rapacity after an extreme endurance run: The Paris-Dakar foot-race. International Journal of Sports Medicine, 16(6), 343-346. https://doi.org/10.1055/s-2007-973017

Loss of muscle oxidative rapacity after an extreme endurance run : The Paris-Dakar foot-race. / Hochli, D.; Schneiter, T.; Ferretti, G.; Howald, H.; Claassen, H.; Moia, C.; Atchou, G.; Belleri, M.; Veicsteinas, A.; Hoppeler, H.

In: International Journal of Sports Medicine, Vol. 16, No. 6, 1995, p. 343-346.

Research output: Contribution to journalArticle

Hochli, D, Schneiter, T, Ferretti, G, Howald, H, Claassen, H, Moia, C, Atchou, G, Belleri, M, Veicsteinas, A & Hoppeler, H 1995, 'Loss of muscle oxidative rapacity after an extreme endurance run: The Paris-Dakar foot-race', International Journal of Sports Medicine, vol. 16, no. 6, pp. 343-346. https://doi.org/10.1055/s-2007-973017
Hochli, D. ; Schneiter, T. ; Ferretti, G. ; Howald, H. ; Claassen, H. ; Moia, C. ; Atchou, G. ; Belleri, M. ; Veicsteinas, A. ; Hoppeler, H. / Loss of muscle oxidative rapacity after an extreme endurance run : The Paris-Dakar foot-race. In: International Journal of Sports Medicine. 1995 ; Vol. 16, No. 6. pp. 343-346.
@article{0495f22c5f2c48c8a6613d3123c4ab16,
title = "Loss of muscle oxidative rapacity after an extreme endurance run: The Paris-Dakar foot-race",
abstract = "We measured changes in maximal oxygen uptake capacity (V̇O2max), ventilation, heart rate, plasma lactate and speed at the end of an incremental exercise test as a consequence of a relay foot race from Paris to Daltar in 6 subjects. Additionally, anthropometric measurements were taken and muscle biopsies from M. vastus lateralis were obtained before and after the race. The latter were analyzed with morphometric methods for fiber size, capillarity and muscle ultrastructural composition. Weight specific V̇O2max was significantly reduced from 62.4 to 60.5 ml/min . kg after the race while absolute V̇O2max and the other endurance related functional variables remained unchanged. Body fat, thigh cross-sectional area and thigh volume showed tendential reduction immediately after the race but regained pre-race values within a few days. Fiber size and capillarity were not affected by the race. Volume density of total mitochondria was significantly reduced from 6.98 to 4.89{\%} of fiber volume. Both subsarcolemmal and interfibrillar mitochondria were significantly reduced by 59 and 21{\%}, respectively. The volume density of satellite cell was increased about three-fold whereas the content of lipofuscin remained constant. It is concluded that extreme endurance events such as a multi-stage relay race may induce a considerable loss of oxidative capacity of skeletal muscle tissue.",
keywords = "Maximum O consumption, Mitochondria, Running, Training",
author = "D. Hochli and T. Schneiter and G. Ferretti and H. Howald and H. Claassen and C. Moia and G. Atchou and M. Belleri and A. Veicsteinas and H. Hoppeler",
year = "1995",
doi = "10.1055/s-2007-973017",
language = "English",
volume = "16",
pages = "343--346",
journal = "International Journal of Sports Medicine",
issn = "0172-4622",
publisher = "Georg Thieme Verlag",
number = "6",

}

TY - JOUR

T1 - Loss of muscle oxidative rapacity after an extreme endurance run

T2 - The Paris-Dakar foot-race

AU - Hochli, D.

AU - Schneiter, T.

AU - Ferretti, G.

AU - Howald, H.

AU - Claassen, H.

AU - Moia, C.

AU - Atchou, G.

AU - Belleri, M.

AU - Veicsteinas, A.

AU - Hoppeler, H.

PY - 1995

Y1 - 1995

N2 - We measured changes in maximal oxygen uptake capacity (V̇O2max), ventilation, heart rate, plasma lactate and speed at the end of an incremental exercise test as a consequence of a relay foot race from Paris to Daltar in 6 subjects. Additionally, anthropometric measurements were taken and muscle biopsies from M. vastus lateralis were obtained before and after the race. The latter were analyzed with morphometric methods for fiber size, capillarity and muscle ultrastructural composition. Weight specific V̇O2max was significantly reduced from 62.4 to 60.5 ml/min . kg after the race while absolute V̇O2max and the other endurance related functional variables remained unchanged. Body fat, thigh cross-sectional area and thigh volume showed tendential reduction immediately after the race but regained pre-race values within a few days. Fiber size and capillarity were not affected by the race. Volume density of total mitochondria was significantly reduced from 6.98 to 4.89% of fiber volume. Both subsarcolemmal and interfibrillar mitochondria were significantly reduced by 59 and 21%, respectively. The volume density of satellite cell was increased about three-fold whereas the content of lipofuscin remained constant. It is concluded that extreme endurance events such as a multi-stage relay race may induce a considerable loss of oxidative capacity of skeletal muscle tissue.

AB - We measured changes in maximal oxygen uptake capacity (V̇O2max), ventilation, heart rate, plasma lactate and speed at the end of an incremental exercise test as a consequence of a relay foot race from Paris to Daltar in 6 subjects. Additionally, anthropometric measurements were taken and muscle biopsies from M. vastus lateralis were obtained before and after the race. The latter were analyzed with morphometric methods for fiber size, capillarity and muscle ultrastructural composition. Weight specific V̇O2max was significantly reduced from 62.4 to 60.5 ml/min . kg after the race while absolute V̇O2max and the other endurance related functional variables remained unchanged. Body fat, thigh cross-sectional area and thigh volume showed tendential reduction immediately after the race but regained pre-race values within a few days. Fiber size and capillarity were not affected by the race. Volume density of total mitochondria was significantly reduced from 6.98 to 4.89% of fiber volume. Both subsarcolemmal and interfibrillar mitochondria were significantly reduced by 59 and 21%, respectively. The volume density of satellite cell was increased about three-fold whereas the content of lipofuscin remained constant. It is concluded that extreme endurance events such as a multi-stage relay race may induce a considerable loss of oxidative capacity of skeletal muscle tissue.

KW - Maximum O consumption

KW - Mitochondria

KW - Running

KW - Training

UR - http://www.scopus.com/inward/record.url?scp=0029130096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029130096&partnerID=8YFLogxK

U2 - 10.1055/s-2007-973017

DO - 10.1055/s-2007-973017

M3 - Article

VL - 16

SP - 343

EP - 346

JO - International Journal of Sports Medicine

JF - International Journal of Sports Medicine

SN - 0172-4622

IS - 6

ER -