Abstract
We evaluated plasma osmolality (pOsm), thirst, and vasopressin response to hypertonic saline infusion in 14 patients with multiple system atrophy (MSA). This disease is characterized by the degeneration of noradrenergic neurons in the central nervous system and severe orthostatic hypotension. Seven patients were also characterized by the lack of vasopressin response to hypotension (group B) and seven by a preserved response (group A). In group A pOsm rose from 290 ± 2 to 312 ± 6 mosmol/kgH2O, vasopressin from 0.9 ± 0.3 to 5.7 ± 0.5 pmol/l, and thirst from 1.1 ± 0.1 to 8.7 ± 1.1 cm on the visual analog scale. After saline, patients drank 1,215 ± 150 ml of water (no different from healthy controls). In group B patients' pOsm rose from 296 ± 3 to 325 ± 6 mosmol/kgH2O and vasopressin from 1.2 ± 0.1 to 19.6 ± 0.4 pmol/l (P <0.01 vs. group A and controls). Group B patients had no thirst during saline and drank little after the challenge (175 ± 50 ml; P <0.01 vs. group A and control). Forced drinking decreased vasopressin in patients before changes in pOsm, showing that inhibitory afferents from oropharyngeal mucosa were intact. In MSA patients with altered afferent control of vasopressin there is a dissociation between the osmotic control of thirst and the osmotic control of vasopressin.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 266 |
| Issue number | 6 35-6 |
| Publication status | Published - 1994 |
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Keywords
- anteroventral third ventricle
- catecholamine depletion
- osmolality
- sinoaortic deafferentation
- thirst
- vasopressin
ASJC Scopus subject areas
- Physiology
Cite this
Loss of osmotic thirst in multiple system atrophy : Association with sinoaortic baroreceptor deafferentation. / Bevilacqua, M.; Norbiato, G.; Righini, V.; Vago, T.; Castelli, L.; Carella, F.; Caraceni, T.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 266, No. 6 35-6, 1994.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Loss of osmotic thirst in multiple system atrophy
T2 - Association with sinoaortic baroreceptor deafferentation
AU - Bevilacqua, M.
AU - Norbiato, G.
AU - Righini, V.
AU - Vago, T.
AU - Castelli, L.
AU - Carella, F.
AU - Caraceni, T.
PY - 1994
Y1 - 1994
N2 - We evaluated plasma osmolality (pOsm), thirst, and vasopressin response to hypertonic saline infusion in 14 patients with multiple system atrophy (MSA). This disease is characterized by the degeneration of noradrenergic neurons in the central nervous system and severe orthostatic hypotension. Seven patients were also characterized by the lack of vasopressin response to hypotension (group B) and seven by a preserved response (group A). In group A pOsm rose from 290 ± 2 to 312 ± 6 mosmol/kgH2O, vasopressin from 0.9 ± 0.3 to 5.7 ± 0.5 pmol/l, and thirst from 1.1 ± 0.1 to 8.7 ± 1.1 cm on the visual analog scale. After saline, patients drank 1,215 ± 150 ml of water (no different from healthy controls). In group B patients' pOsm rose from 296 ± 3 to 325 ± 6 mosmol/kgH2O and vasopressin from 1.2 ± 0.1 to 19.6 ± 0.4 pmol/l (P <0.01 vs. group A and controls). Group B patients had no thirst during saline and drank little after the challenge (175 ± 50 ml; P <0.01 vs. group A and control). Forced drinking decreased vasopressin in patients before changes in pOsm, showing that inhibitory afferents from oropharyngeal mucosa were intact. In MSA patients with altered afferent control of vasopressin there is a dissociation between the osmotic control of thirst and the osmotic control of vasopressin.
AB - We evaluated plasma osmolality (pOsm), thirst, and vasopressin response to hypertonic saline infusion in 14 patients with multiple system atrophy (MSA). This disease is characterized by the degeneration of noradrenergic neurons in the central nervous system and severe orthostatic hypotension. Seven patients were also characterized by the lack of vasopressin response to hypotension (group B) and seven by a preserved response (group A). In group A pOsm rose from 290 ± 2 to 312 ± 6 mosmol/kgH2O, vasopressin from 0.9 ± 0.3 to 5.7 ± 0.5 pmol/l, and thirst from 1.1 ± 0.1 to 8.7 ± 1.1 cm on the visual analog scale. After saline, patients drank 1,215 ± 150 ml of water (no different from healthy controls). In group B patients' pOsm rose from 296 ± 3 to 325 ± 6 mosmol/kgH2O and vasopressin from 1.2 ± 0.1 to 19.6 ± 0.4 pmol/l (P <0.01 vs. group A and controls). Group B patients had no thirst during saline and drank little after the challenge (175 ± 50 ml; P <0.01 vs. group A and control). Forced drinking decreased vasopressin in patients before changes in pOsm, showing that inhibitory afferents from oropharyngeal mucosa were intact. In MSA patients with altered afferent control of vasopressin there is a dissociation between the osmotic control of thirst and the osmotic control of vasopressin.
KW - anteroventral third ventricle
KW - catecholamine depletion
KW - osmolality
KW - sinoaortic deafferentation
KW - thirst
KW - vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0028242580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028242580&partnerID=8YFLogxK
M3 - Article
C2 - 8024024
AN - SCOPUS:0028242580
VL - 266
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 6 35-6
ER -