Loss of renal function in the elderly Italians: A physiologic or pathologic process?

Ciro Esposito, Massimo Torreggiani, Marta Arazzi, Nicoletta Serpieri, Maria Lucia Scaramuzzi, Alessandra Manini, Fabrizio Grosjean, Vittoria Esposito, Davide Catucci, Edoardo La Porta, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review


Background. Nowadays it seems that chronic kidney disease (CKD) is outbreaking, mostly in the elderly participants. The aim of this study was to assess the progression of CKD in different ages.Methods. We conducted a monocentric, retrospective, observational study enrolling 116 patients afferent to our outpatient clinic. Inclusion criteria: age >18 years, follow-up ≥5 years, estimated glomerular filtration rate (eGFR) 2, and/or diagnosed renal disease and/or presence of renal damage. Patients were divided into four groups according to their age: 25-55 years (n = 27), 56-65 (25), 66-75 (42), and 76-87 (22). eGFR was calculated using the modification of diet in renal disease and the CKD-epidemiology collaboration formulas.Results. Younger patients had a significantly longer follow-up and less comorbidities, evaluated by the cumulative illness rating scale score, compared with the other groups. There was no difference between creatinine at baseline and at the end-of-follow-up period among the groups. Even though renal function significantly decreased in all groups, we noticed a slower progression as the age increased, and the difference between basal and end-of-follow-up eGFR was minimal in the group of patients aged 76-87 years. Analyzing the eGFR of every ambulatory control plotted against the year of follow-up, we showed a more rapid loss of filtrate in the younger group. Instead, loss of renal function decreased as the age of patients increased.Conclusions. This study demonstrates that, in elderly Italian participants, progression of CKD occurs more slowly than in younger patients. This implies that we may probably face an epidemic of CKD but that most of elderly patients diagnosed with CKD may not evolve to end-stage renal disease and require renal replacement therapy.

Original languageEnglish
Pages (from-to)1387-1393
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number12
Publication statusPublished - Dec 2012


  • Aging
  • Chronic kidney disease
  • Progression

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)


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