Loss of retinoschisin (RS1) cell surface protein in maturing mouse rod photoreceptors elevates the luminance threshold for light-driven translocation of transducin but not arrestin

Lucia Ziccardi, Camasamudram Vijayasarathy, Ronald A. Bush, Paul A. Sieving

Research output: Contribution to journalArticle

Abstract

Loss of retinoschisin (RS1) in Rs1 knock-out (Rs1-KO) retina produces a post-photoreceptor phenotype similar to X-linked retinoschisis in young males. However, Rs1 is expressed strongly in photoreceptors, and Rs1-KO mice have early reduction in the electroretinogram a-wave. We examined light-activated transducin and arrestin translocation in young Rs1-KO mice as a marker for functional abnormalities in maturing rod photoreceptors. We found a progressive reduction in luminance threshold for transducin translocation in wild-type (WT) retinas between postnatal days P18 and P60. At P21, the threshold in Rs1-KO retinas was 10-fold higher than WT, but it decreased to

Original languageEnglish
Pages (from-to)13010-13021
Number of pages12
JournalJournal of Neuroscience
Volume32
Issue number38
DOIs
Publication statusPublished - Sep 19 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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