L’ottimizzazione terapeutica nel percorso del paziente con scompenso cardiaco

Pietro Ameri, Antonio Francesco Amico, Alessandro Battagliese, Sergio Berra, Paolo Calabrò, Marco Candela, Francesco Clemenza, Giovambattista Desideri, Giuseppe Di Tano, Fernando Gallucci, Arianna Gardin, Massimo Iacoviello, Giuseppe Leonardi, Riccardo Morgagni, Andrea Mortara, Alberto Palazzuoli, Stefania Paolillo, Pasquale Perrone Filardi, Massimo Volpe

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure (HF) is still characterized by high mortality rates, despite the progress achieved in terms of treatment options. With regard to the treatment of HF with reduced ejection fraction (HFrEF), the 2016 European Society of Cardiology guidelines included in the therapeutic algorithm the angiotensin receptor-neprilysin inhibitor class, whose efficacy in modifying patient prognosis has been extensively proven in many clinical studies. Sacubitril/valsartan, the only representative of this drug class, can effectively affect the natural history of HF, thus reducing cardiovascular mortality (sudden death and death due to worsening cardiac function), total mortality, as well as first and recurrent hospitalization events, by improving renal function, cardiac remodeling, functional capacity and the patient's health-related quality of life.The purpose of this article is to analyze the different phases of the journey of patients with HFrEF (first general practitioner consultation; admission to the emergency department and subsequent hospitalization; referral to a specialist HF clinic) and promotion of a networking approach involving the general practitioner, the hospital and the HF specialist based on common pre-defined diagnostic and therapeutic protocols, that meets patient needs at all stages of the disease (case-specific dosing assessment, drug titration before follow-up and prevention of adverse events).
Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalGiornale Italiano di Cardiologia
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2020

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