Lovastatin dose-dependently potentiates the pro-inflammatory activity of lipopolysaccharide both in vitro and in vivo

Valentina Zanin, Annalisa Marcuzzi, Giulio Kleiner, Elisa Piscianz, Lorenzo Monasta, Serena Zacchigna, Sergio Crovella, Giorgio Zauli

Research output: Contribution to journalArticlepeer-review

Abstract

Since contradictory findings have been reported on potential effects of statins in modulating the inflammatory response, we have analysed the biological activity of lovastatin both in vitro using the Raw 264.7 murine macrophagic cell line and in vivo using BALB/c mice. When added to Raw 264.7 cells in combination with lipopolysaccharide, lovastatin significantly potentiated the release of interleukin-1β, interleukin-6 and interleukin-12 with respect to lipopolysaccharide alone and showed an additive effect on the release of nitric oxide. Similarly, when lovastatin was intraperitoneally administrated to BALB/c mice, it did not induce any pro-inflammatory effect when used alone, but it significantly potentiated the pro-inflammatory activity of lipopolysaccharide, in terms of number of intraperitoneal cells and serum levels of serum amyloid A, interleukin-1β, interleukin-6 and interleukin-12. A potential clinical implication of our study is that lovastatin might exert a pro-inflammatory activity in subjects affected by inflammatory processes, with clinically evident or subclinical infections.

Original languageEnglish
Pages (from-to)981-988
Number of pages8
JournalJournal of Cardiovascular Translational Research
Volume6
Issue number6
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Cholesterol
  • Cytokines
  • Inflammation
  • Statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

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