Low abdominal contribution to breathing as daytime predictor of nocturnal desaturation in adolescents and young adults with Duchenne Muscular Dystrophy

M. Romei, M. G. D'Angelo, A. Lomauro, S. Gandossini, S. Bonato, E. Brighina, E. Marchi, G. P. Comi, A. C. Turconi, A. Pedotti, N. Bresolin, A. Aliverti

Research output: Contribution to journalArticle

Abstract

In the respiratory management of DMD patients it is still under debate what parameter should indicate the correct timing for institution of nocturnal non-invasive ventilation (NIV), in addition to forced vital capacity, which is generally considered as a prognostic marker of disease progression. The aim of this study was to determine if volume variations of rib cage and abdominal compartments measured by Opto-Electronic Plethysmography can be helpful to distinguish between those patients who are in the early stages of nocturnal oxygen desaturation development and those who do not yet. Pulmonary function, abdominal contribution to tidal volume and to inspiratory capacity (%Abd IC) and a set of breathing pattern indexes were assessed in 40 DMD patients older than 14 years and not yet under nocturnal NIV. ROC analysis revealed that among all the considered parameters, %Abd IC in supine position was the best discriminator between DeSat (at least 10% of the night time with SpO 2 <95%) and NonDeSat patients, providing an area under the curve with 95%CI equal to 0.752. In conclusion, in adolescents and adults DMD patients who present either no sign or only mild nocturnal oxygen desaturation, a reduced abdominal contribution to inspiratory capacity is a marker of the onset of diaphragm weakness and should be considered to identify the correct timing for the institution of nocturnal NIV.

Original languageEnglish
Pages (from-to)276-283
Number of pages8
JournalRespiratory Medicine
Volume106
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Duchenne Muscular Dystrophy
Young Adult
Respiration
Noninvasive Ventilation
Inspiratory Capacity
Oxygen
Plethysmography
Supine Position
Tidal Volume
Vital Capacity
Diaphragm
ROC Curve
Area Under Curve
Disease Progression
Lung

Keywords

  • Abdomen
  • Diaphragm
  • Duchenne Muscular Dystrophy
  • Nocturnal hypoxemia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Low abdominal contribution to breathing as daytime predictor of nocturnal desaturation in adolescents and young adults with Duchenne Muscular Dystrophy. / Romei, M.; D'Angelo, M. G.; Lomauro, A.; Gandossini, S.; Bonato, S.; Brighina, E.; Marchi, E.; Comi, G. P.; Turconi, A. C.; Pedotti, A.; Bresolin, N.; Aliverti, A.

In: Respiratory Medicine, Vol. 106, No. 2, 02.2012, p. 276-283.

Research output: Contribution to journalArticle

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