Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis

Milena Di Leo, Gioacchino Leandro, Satish K Singh, Alberto Mariani, Margherita Bianco, Raffaella Alessia Zuppardo, Elisabetta Goni, Teresa Marzia Rogger, Francesco Di Mario, Mario Guslandi, Francesco De Cobelli, Alessandro Del Maschio, Pier Alberto Testoni, Giulia Martina Cavestro

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP).

METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome.

RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35).

CONCLUSIONS: In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalPancreas
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2017

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Chronic Pancreatitis
Tobacco Products
Alcohols
Smoking
Magnetic Resonance Cholangiopancreatography
Secretin
Irritable Bowel Syndrome
Odds Ratio
Pancreatic Diseases
Sex Ratio
ROC Curve
Sex Characteristics
Alcohol Drinking
Drinking
Habits
Pancreas
Multivariate Analysis
Population

Keywords

  • Journal Article

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Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis. / Di Leo, Milena; Leandro, Gioacchino; Singh, Satish K; Mariani, Alberto; Bianco, Margherita; Zuppardo, Raffaella Alessia; Goni, Elisabetta; Rogger, Teresa Marzia; Di Mario, Francesco; Guslandi, Mario; De Cobelli, Francesco; Del Maschio, Alessandro; Testoni, Pier Alberto; Cavestro, Giulia Martina.

In: Pancreas, Vol. 46, No. 2, 02.2017, p. 225-229.

Research output: Contribution to journalArticle

Di Leo, M, Leandro, G, Singh, SK, Mariani, A, Bianco, M, Zuppardo, RA, Goni, E, Rogger, TM, Di Mario, F, Guslandi, M, De Cobelli, F, Del Maschio, A, Testoni, PA & Cavestro, GM 2017, 'Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis', Pancreas, vol. 46, no. 2, pp. 225-229. https://doi.org/10.1097/MPA.0000000000000737
Di Leo, Milena ; Leandro, Gioacchino ; Singh, Satish K ; Mariani, Alberto ; Bianco, Margherita ; Zuppardo, Raffaella Alessia ; Goni, Elisabetta ; Rogger, Teresa Marzia ; Di Mario, Francesco ; Guslandi, Mario ; De Cobelli, Francesco ; Del Maschio, Alessandro ; Testoni, Pier Alberto ; Cavestro, Giulia Martina. / Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis. In: Pancreas. 2017 ; Vol. 46, No. 2. pp. 225-229.
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AU - Bianco, Margherita

AU - Zuppardo, Raffaella Alessia

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AU - Rogger, Teresa Marzia

AU - Di Mario, Francesco

AU - Guslandi, Mario

AU - De Cobelli, Francesco

AU - Del Maschio, Alessandro

AU - Testoni, Pier Alberto

AU - Cavestro, Giulia Martina

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N2 - OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP).METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome.RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35).CONCLUSIONS: In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.

AB - OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP).METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome.RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35).CONCLUSIONS: In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.

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