Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis

M Di Leo, G Leandro, SK Singh, A. Mariani, M Bianco, RA Zuppardo, E Goni, TM Rogger, F Di Mario, Mario Guslandi, F de Cobelli, A Del Maschio, PA Testoni, GM Cavestro

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP). METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome. RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35). CONCLUSIONS: In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalPancreas
Volume46
Issue number2
DOIs
Publication statusPublished - 2017

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