TY - JOUR
T1 - Low bone mineral density and its predictors in type 1 diabetic patients evaluated by the classic statistics and artificial neural network analysis
AU - Eller-Vainicher, Cristina
AU - Zhukouskaya, Volha V.
AU - Tolkachev, Yury V.
AU - Koritko, Sergei S.
AU - Cairoli, Elisa
AU - Grossi, Enzo
AU - Beck-Peccoz, Paolo
AU - Chiodini, Iacopo
AU - Shepelkevich, Alla P.
PY - 2011/10
Y1 - 2011/10
N2 - OBJECTIVE - To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS - A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) were studied. In all subjects, BMI and BMD (as Z score) at the lumbar spine (LS-BMD) and femur (F-BMD) were measured. Daily insulin dose (DID), age at diagnosis, presence of complications, creatinine clearance (ClCr), and HbA 1c were determined. RESULTS - LS- and F-BMD levels were lower in patients (20.11 ± 1.2 and 20.32 ± 1.4, respectively) than in control subjects (0.59 ± 1, P <0.0001, and 0.63 ± 1, P <0.0001, respectively). LS-BMD was independently associated with BMI and DID, whereas F-BMD was associated with BMI and ClCr. The cutoffs for predicting low BMD were as follows: BMI 2, DID >0.67 units/kg, and ClCr
AB - OBJECTIVE - To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS - A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) were studied. In all subjects, BMI and BMD (as Z score) at the lumbar spine (LS-BMD) and femur (F-BMD) were measured. Daily insulin dose (DID), age at diagnosis, presence of complications, creatinine clearance (ClCr), and HbA 1c were determined. RESULTS - LS- and F-BMD levels were lower in patients (20.11 ± 1.2 and 20.32 ± 1.4, respectively) than in control subjects (0.59 ± 1, P <0.0001, and 0.63 ± 1, P <0.0001, respectively). LS-BMD was independently associated with BMI and DID, whereas F-BMD was associated with BMI and ClCr. The cutoffs for predicting low BMD were as follows: BMI 2, DID >0.67 units/kg, and ClCr
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U2 - 10.2337/dc11-0764
DO - 10.2337/dc11-0764
M3 - Article
C2 - 21852680
AN - SCOPUS:84860806361
VL - 34
SP - 2186
EP - 2191
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 10
ER -