Low contrast stimuli enhance PERG sensitivity to the visual dysfunction in Parkinson's disease

A. Peppe, P. Stanzione, F. Pierelli, E. Stefano, P. A. Rizzo, M. Tagliati, C. Morocutti

Research output: Contribution to journalArticlepeer-review

Abstract

The pattern electroretinogram (PERG) was recorded at different contrast levels (96%, 71%, 47%) in 10 Parkinson's disease patients before and during dopaminergic monotherapy. The data were compared to a control group of 8 normal subjects recorded with the same procedure. PERG P50 latency progressively increased as contrast was decreased both in normal subjects and patients; however, this trend was much more pronounced in PD patients without therapy; consequently in this group the difference between P50 latency obtained with 96% and 47% contrast was statistically significant (P = 0.01, analysis of variance corrected by post-hoc Tukey test). By contrast this was not seen in the control group. Statistical analysis (Bonferroni's t test) showed at the 47% contrast level a significant P50 latency increase (P <0.01) in PD patients without therapy if compared with the control group. Dopaminergic monotherapy induced a P50 latency recovery in PD patients. We conclude that low contrast stimuli enhance PERG sensitivity to the visual dysfunction of PD patients. Moreover, the effects observed after therapy confirm that abnormal contrast response functions in PD patients are linked to dopaminergic deficiency.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology
Volume82
Issue number6
DOIs
Publication statusPublished - 1992

Keywords

  • Contrast sensitivity
  • Parkinson's disease
  • Pattern electroretinogram

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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