Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

Translated title of the contribution: Low-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment

Cristina Arbona, Sergio Martinez-Hervás, Rosa Goterris, Juan Montoro, José Tomás Real, Juan Francisco Ascaso

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

Translated title of the contributionLow-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment
Original languageSpanish
Pages (from-to)207-210
Number of pages4
JournalMedicina Clinica
Volume140
Issue number5
DOIs
Publication statusPublished - Mar 2 2013

Keywords

  • Familial hypercholesterolemia
  • Low-density lipoprotein apheresis
  • Statin resistance

ASJC Scopus subject areas

  • Medicine(all)

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