Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

Translated title of the contribution: Low-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment

Cristina Arbona, Sergio Martinez-Hervás, Rosa Goterris, Juan Montoro, José Tomás Real, Juan Francisco Ascaso

Research output: Contribution to journalArticle

Abstract

Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

Original languageSpanish
Pages (from-to)207-210
Number of pages4
JournalMedicina Clinica
Volume140
Issue number5
DOIs
Publication statusPublished - Mar 2 2013

Fingerprint

Hyperlipoproteinemia Type II
Blood Component Removal
LDL Lipoproteins
Apolipoproteins B
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Secondary Prevention
Pharmaceutical Preparations

Keywords

  • Familial hypercholesterolemia
  • Low-density lipoprotein apheresis
  • Statin resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo. / Arbona, Cristina; Martinez-Hervás, Sergio; Goterris, Rosa; Montoro, Juan; Real, José Tomás; Ascaso, Juan Francisco.

In: Medicina Clinica, Vol. 140, No. 5, 02.03.2013, p. 207-210.

Research output: Contribution to journalArticle

Arbona, Cristina ; Martinez-Hervás, Sergio ; Goterris, Rosa ; Montoro, Juan ; Real, José Tomás ; Ascaso, Juan Francisco. / Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo. In: Medicina Clinica. 2013 ; Vol. 140, No. 5. pp. 207-210.
@article{5e30a72b0e01457eaa5cae913e63f787,
title = "Af{\'e}resis de lipoprote{\'i}nas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento m{\'e}dico convencional intensivo",
abstract = "Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20{\%}. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3{\%} decrease in LDL-C and 58.2{\%} in apoB plasma values (P",
keywords = "Familial hypercholesterolemia, Low-density lipoprotein apheresis, Statin resistance",
author = "Cristina Arbona and Sergio Martinez-Herv{\'a}s and Rosa Goterris and Juan Montoro and Real, {Jos{\'e} Tom{\'a}s} and Ascaso, {Juan Francisco}",
year = "2013",
month = "3",
day = "2",
doi = "10.1016/j.medcli.2012.02.024",
language = "Spagnolo",
volume = "140",
pages = "207--210",
journal = "Medicina Clinica",
issn = "0025-7753",
publisher = "Ediciones Doyma, S.L.",
number = "5",

}

TY - JOUR

T1 - Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

AU - Arbona, Cristina

AU - Martinez-Hervás, Sergio

AU - Goterris, Rosa

AU - Montoro, Juan

AU - Real, José Tomás

AU - Ascaso, Juan Francisco

PY - 2013/3/2

Y1 - 2013/3/2

N2 - Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

AB - Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

KW - Familial hypercholesterolemia

KW - Low-density lipoprotein apheresis

KW - Statin resistance

UR - http://www.scopus.com/inward/record.url?scp=84874762860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874762860&partnerID=8YFLogxK

U2 - 10.1016/j.medcli.2012.02.024

DO - 10.1016/j.medcli.2012.02.024

M3 - Articolo

C2 - 22571847

AN - SCOPUS:84874762860

VL - 140

SP - 207

EP - 210

JO - Medicina Clinica

JF - Medicina Clinica

SN - 0025-7753

IS - 5

ER -