Abstract
Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P
| Original language | Spanish |
|---|---|
| Pages (from-to) | 207-210 |
| Number of pages | 4 |
| Journal | Medicina Clinica |
| Volume | 140 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Mar 2 2013 |
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Keywords
- Familial hypercholesterolemia
- Low-density lipoprotein apheresis
- Statin resistance
ASJC Scopus subject areas
- Medicine(all)
Cite this
Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo. / Arbona, Cristina; Martinez-Hervás, Sergio; Goterris, Rosa; Montoro, Juan; Real, José Tomás; Ascaso, Juan Francisco.
In: Medicina Clinica, Vol. 140, No. 5, 02.03.2013, p. 207-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo
AU - Arbona, Cristina
AU - Martinez-Hervás, Sergio
AU - Goterris, Rosa
AU - Montoro, Juan
AU - Real, José Tomás
AU - Ascaso, Juan Francisco
PY - 2013/3/2
Y1 - 2013/3/2
N2 - Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P
AB - Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P
KW - Familial hypercholesterolemia
KW - Low-density lipoprotein apheresis
KW - Statin resistance
UR - http://www.scopus.com/inward/record.url?scp=84874762860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874762860&partnerID=8YFLogxK
U2 - 10.1016/j.medcli.2012.02.024
DO - 10.1016/j.medcli.2012.02.024
M3 - Articolo
C2 - 22571847
AN - SCOPUS:84874762860
VL - 140
SP - 207
EP - 210
JO - Medicina Clinica
JF - Medicina Clinica
SN - 0025-7753
IS - 5
ER -