Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

Cristina Arbona; Sergio Martinez-Hervás; Rosa Goterris; Juan Montoro; José Tomás Real; Juan Francisco Ascaso

doi:10.1016/j.medcli.2012.02.024

Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

Translated title of the contribution: Low-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment

Cristina Arbona, Sergio Martinez-Hervás, Rosa Goterris, Juan Montoro, José Tomás Real, Juan Francisco Ascaso

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

Translated title of the contribution	Low-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment
Original language	Spanish
Pages (from-to)	207-210
Number of pages	4
Journal	Medicina Clinica
Volume	140
Issue number	5
DOIs	https://doi.org/10.1016/j.medcli.2012.02.024
Publication status	Published - Mar 2 2013

Keywords

Familial hypercholesterolemia
Low-density lipoprotein apheresis
Statin resistance

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.medcli.2012.02.024

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Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo. / Arbona, Cristina; Martinez-Hervás, Sergio; Goterris, Rosa; Montoro, Juan; Real, José Tomás; Ascaso, Juan Francisco.

In: Medicina Clinica, Vol. 140, No. 5, 02.03.2013, p. 207-210.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P ",

keywords = "Familial hypercholesterolemia, Low-density lipoprotein apheresis, Statin resistance",

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AU - Arbona, Cristina

AU - Martinez-Hervás, Sergio

AU - Goterris, Rosa

AU - Montoro, Juan

AU - Real, José Tomás

AU - Ascaso, Juan Francisco

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AB - Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P

KW - Familial hypercholesterolemia

KW - Low-density lipoprotein apheresis

KW - Statin resistance

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Aféresis de lipoproteínas de baja densidad en la hipercolesterolemia familiar resistente al tratamiento médico convencional intensivo

Abstract

Keywords

ASJC Scopus subject areas

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