Abstract
Background and objective: The aim of our study is to analyze the effect and security of low-density lipoproteins (LDL) apheresis in familial hypercholesterolemia (FH) subjects who did not response to conventional intensive optimized medical treatment. Patients and methods: Seven heterozygous FH subjects and one homozygous apoB familial defective were studied. All subjects were on secondary prevention with highest statins doses in association with other hypolipemiant drugs; the mean LDL-C reduction was 20%. All of them were treated with LDL apheresis (immunoabsorption) for a mean of 4.25 years. Results: LDL apheresis resulted in a 68.3% decrease in LDL-C and 58.2% in apoB plasma values (P
Translated title of the contribution | Low-density lipoprotein apheresis in familial hypercholesterolemia resistant to intensive medical treatment |
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Original language | Spanish |
Pages (from-to) | 207-210 |
Number of pages | 4 |
Journal | Medicina Clinica |
Volume | 140 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2 2013 |
Keywords
- Familial hypercholesterolemia
- Low-density lipoprotein apheresis
- Statin resistance
ASJC Scopus subject areas
- Medicine(all)