Low density lipoprotein receptors and polyamine levels in human colorectal adenocarcinoma

Maria Notarnicola, Michele Linsalata, Maria Gabriella Caruso, Aldo Cavallini, Alfredo Di Leo

Research output: Contribution to journalArticle

Abstract

The low density lipoprotein receptor (LDLR) is a cell surface protein that binds with LDL, providing the cell with cholesterol for new membrane synthesis. Rapidly growing cells have high numbers of LDLRs, and these proteins have also been detected in neoplastic samples of human colorectal mucosa. Polyamines, putrescine, spermidine, and spermine, play an important role in cellular growth, and studies on colorectal cancers have demonstrated higher polyamine levels in neoplastic mucosa samples than in surrounding mucosa. The aim of this study was to investigate LDLR and polyamine levels in the neoplastic tissue of 43 patients (28 males and 15 females) with colorectal adenocarcinoma, using enzymatic immunoassay and high performance liquid chromatography, respectively. Specimens of neoplastic mucosa were considered LDLR-positive or LDLR-negative when the amount of bound anti-LDLR Ab/mg protein), respectively. Twenty-one subjects were LDLR-positive and 22 LDLR-negative. Polyamine levels (nmol/g tissue) were higher in LDLR-positive specimens; this increase was significant for total polyamines (P

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalJournal of Gastroenterology
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 1995

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Keywords

  • colorectal adenocarcinoma
  • LDL
  • polyamines
  • receptor

ASJC Scopus subject areas

  • Gastroenterology

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