Low dosage cidofovir without probenecid as treatment for bk virus hamorrhagic cystitis after hemopoietic stem cell transplant

Maura Faraci, Daniela Cuzzubbo, Edoardo Lanino, Eddi Di Marco, Carmela Cirillo, Sandro Dallorso, Giuseppe Morreale, Cristina Moroni, Elio Castagnola

Research output: Contribution to journalArticle

Abstract

We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalPediatric Infectious Disease Journal
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Probenecid
Cystitis
Stem Cells
BK Virus
Viruses
Transplants
Viral Load
Pediatrics
Therapeutics
cidofovir

Keywords

  • BK virus
  • cidofovir
  • hemorrhagic cystitis
  • probenecid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

@article{1e383ede92c6445ba0b06f85a6367282,
title = "Low dosage cidofovir without probenecid as treatment for bk virus hamorrhagic cystitis after hemopoietic stem cell transplant",
abstract = "We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.",
keywords = "BK virus, cidofovir, hemorrhagic cystitis, probenecid",
author = "Maura Faraci and Daniela Cuzzubbo and Edoardo Lanino and {Di Marco}, Eddi and Carmela Cirillo and Sandro Dallorso and Giuseppe Morreale and Cristina Moroni and Elio Castagnola",
year = "2009",
month = "1",
doi = "10.1097/INF.0b013e3181812cb9",
language = "English",
volume = "28",
pages = "55--57",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Low dosage cidofovir without probenecid as treatment for bk virus hamorrhagic cystitis after hemopoietic stem cell transplant

AU - Faraci, Maura

AU - Cuzzubbo, Daniela

AU - Lanino, Edoardo

AU - Di Marco, Eddi

AU - Cirillo, Carmela

AU - Dallorso, Sandro

AU - Morreale, Giuseppe

AU - Moroni, Cristina

AU - Castagnola, Elio

PY - 2009/1

Y1 - 2009/1

N2 - We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.

AB - We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.

KW - BK virus

KW - cidofovir

KW - hemorrhagic cystitis

KW - probenecid

UR - http://www.scopus.com/inward/record.url?scp=66149101543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149101543&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3181812cb9

DO - 10.1097/INF.0b013e3181812cb9

M3 - Article

C2 - 19057462

AN - SCOPUS:66149101543

VL - 28

SP - 55

EP - 57

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 1

ER -