Low dosage clozapine effects on L-dopa induced dyskinesias in parkinsonian patients

F. Pierelli, A. Adipietro, G. Soldati, F. Fattapposta, G. Pozzessere, C. Scoppetta

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives - The aim of this study was to investigate the clinical efficacy of clozapine, an atypical neuroleptic, on L-dopa induced dyskinesias of Parkinson's disease. Material and methods -In an open study, a group of 10 PD patients was treated with low dosage clozapine (mean 30 mg/day) for a 4- month period and L-dopa dyskinesias were evaluated in basal conditions and during clozapine treatment after the usual morning dose of clozapine. We utilized the AIMS for evaluation of dyskinesias and UPDRS for the assessment of motor performances. Results - Clozapine produced a significant (P

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalActa Neurologica Scandinavica
Volume97
Issue number5
Publication statusPublished - 1998

Keywords

  • Clozapine
  • Dyskinesias
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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