Low-dose aspirin in polycythaemia vera: A pilot study

T. Barbui; G. de Gaetano; G. Finazzi; Raffaele Landolfi; R. Marchioli; C. Patrono; G. Tognoni; F. Capani; A. De Carli; D. Gambi; G. G. Nenci; S. Tura; F. Mandelli; P. Rossi-Ferrini; T. Barbui; S. Cortelazzo; G. Finazzi; O. Vestri; S. Tura; C. Finelli; F. Nocentini; E. M. Pogliani; I. R. Miccolis; B. Bizzi; B. Rocca; R. Tartagilione; G. Angeli; A. Di Blasio; A. Di Pasquale; V. Kramer; R. M. Marfisi; M. Olivieri; L. Sciulli; R. Spoltore; F. Mandelli; E. Montefusco; A. Spadea; M. Carotenuto; M. Nobile; A. Morelli; L. Resegotti; M. A. Ciocca Vasino; F. Rodeghiero; M. Ruggeri; Gruppo Italiano Studio Policitemia (GISP)

doi:10.1046/j.1365-2141.1997.362682.x

Low-dose aspirin in polycythaemia vera: A pilot study

T. Barbui, G. de Gaetano, G. Finazzi, Raffaele Landolfi, R. Marchioli, C. Patrono, G. Tognoni, F. Capani, A. De Carli, D. Gambi, G. G. Nenci, S. Tura, F. Mandelli, P. Rossi-Ferrini, T. Barbui, S. Cortelazzo, G. Finazzi, O. Vestri, S. Tura, C. FinelliF. Nocentini, E. M. Pogliani, I. R. Miccolis, B. Bizzi, B. Rocca, R. Tartagilione, G. Angeli, A. Di Blasio, A. Di Pasquale, V. Kramer, R. M. Marfisi, M. Olivieri, L. Sciulli, R. Spoltore, F. Mandelli, E. Montefusco, A. Spadea, M. Carotenuto, M. Nobile, A. Morelli, L. Resegotti, M. A. Ciocca Vasino, F. Rodeghiero, M. Ruggeri, Gruppo Italiano Studio Policitemia (GISP)

Research output: Contribution to journal › Article

Abstract

In this pilot study, aimed at exploring the feasibility of a large-scale trial of low-dose aspirin in polycythaemia vera (PV), 112 PV patients (42 females, 70 males, aged 17-80 years) were selected for not having a clear indication for, or contraindication to, aspirin treatment and randomized to receive oral aspirin (40 mg/d) or placebo. Follow-up duration was 16 ± 6 months. Measurements of thromboxane A₂ production during whole blood clotting demonstrated complete inhibition of platelet cyclooxygenase activity in patients receiving aspirin. Aspirin administration was not associated with any bleeding complication. Within the limitations of the small sample size, this study indicates that a biochemically effective regimen of antiplatelet therapy is well tolerated in patients with polycythaemia vera and that a large-scale placebo-controlled trial is feasible.

Original language	English
Pages (from-to)	453-456
Number of pages	4
Journal	British Journal of Haematology
Volume	97
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.1997.362682.x
Publication status	Published - 1997

Keywords

Antiplatelet treatment
Aspirin
Polycythaemia vera
Randomized clinical trial
Thromboxane

ASJC Scopus subject areas

Medicine(all)
Hematology

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Barbui, T., de Gaetano, G., Finazzi, G., Landolfi, R., Marchioli, R., Patrono, C., Tognoni, G., Capani, F., De Carli, A., Gambi, D., Nenci, G. G., Tura, S., Mandelli, F., Rossi-Ferrini, P., Barbui, T., Cortelazzo, S., Finazzi, G., Vestri, O., Tura, S., ... Gruppo Italiano Studio Policitemia (GISP) (1997). Low-dose aspirin in polycythaemia vera: A pilot study. British Journal of Haematology, 97(2), 453-456. https://doi.org/10.1046/j.1365-2141.1997.362682.x

Low-dose aspirin in polycythaemia vera : A pilot study. / Barbui, T.; de Gaetano, G.; Finazzi, G.; Landolfi, Raffaele; Marchioli, R.; Patrono, C.; Tognoni, G.; Capani, F.; De Carli, A.; Gambi, D.; Nenci, G. G.; Tura, S.; Mandelli, F.; Rossi-Ferrini, P.; Barbui, T.; Cortelazzo, S.; Finazzi, G.; Vestri, O.; Tura, S.; Finelli, C.; Nocentini, F.; Pogliani, E. M.; Miccolis, I. R.; Bizzi, B.; Rocca, B.; Tartagilione, R.; Angeli, G.; Di Blasio, A.; Di Pasquale, A.; Kramer, V.; Marfisi, R. M.; Olivieri, M.; Sciulli, L.; Spoltore, R.; Mandelli, F.; Montefusco, E.; Spadea, A.; Carotenuto, M.; Nobile, M.; Morelli, A.; Resegotti, L.; Ciocca Vasino, M. A.; Rodeghiero, F.; Ruggeri, M.; Gruppo Italiano Studio Policitemia (GISP).

In: British Journal of Haematology, Vol. 97, No. 2, 1997, p. 453-456.

Research output: Contribution to journal › Article

Barbui, T, de Gaetano, G, Finazzi, G, Landolfi, R, Marchioli, R, Patrono, C, Tognoni, G, Capani, F, De Carli, A, Gambi, D, Nenci, GG, Tura, S, Mandelli, F, Rossi-Ferrini, P, Barbui, T, Cortelazzo, S, Finazzi, G, Vestri, O, Tura, S, Finelli, C, Nocentini, F, Pogliani, EM, Miccolis, IR, Bizzi, B, Rocca, B, Tartagilione, R, Angeli, G, Di Blasio, A, Di Pasquale, A, Kramer, V, Marfisi, RM, Olivieri, M, Sciulli, L, Spoltore, R, Mandelli, F, Montefusco, E, Spadea, A, Carotenuto, M, Nobile, M, Morelli, A, Resegotti, L, Ciocca Vasino, MA, Rodeghiero, F, Ruggeri, M & Gruppo Italiano Studio Policitemia (GISP) 1997, 'Low-dose aspirin in polycythaemia vera: A pilot study', British Journal of Haematology, vol. 97, no. 2, pp. 453-456. https://doi.org/10.1046/j.1365-2141.1997.362682.x

Barbui, T. ; de Gaetano, G. ; Finazzi, G. ; Landolfi, Raffaele ; Marchioli, R. ; Patrono, C. ; Tognoni, G. ; Capani, F. ; De Carli, A. ; Gambi, D. ; Nenci, G. G. ; Tura, S. ; Mandelli, F. ; Rossi-Ferrini, P. ; Barbui, T. ; Cortelazzo, S. ; Finazzi, G. ; Vestri, O. ; Tura, S. ; Finelli, C. ; Nocentini, F. ; Pogliani, E. M. ; Miccolis, I. R. ; Bizzi, B. ; Rocca, B. ; Tartagilione, R. ; Angeli, G. ; Di Blasio, A. ; Di Pasquale, A. ; Kramer, V. ; Marfisi, R. M. ; Olivieri, M. ; Sciulli, L. ; Spoltore, R. ; Mandelli, F. ; Montefusco, E. ; Spadea, A. ; Carotenuto, M. ; Nobile, M. ; Morelli, A. ; Resegotti, L. ; Ciocca Vasino, M. A. ; Rodeghiero, F. ; Ruggeri, M. ; Gruppo Italiano Studio Policitemia (GISP). / Low-dose aspirin in polycythaemia vera : A pilot study. In: British Journal of Haematology. 1997 ; Vol. 97, No. 2. pp. 453-456.

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abstract = "In this pilot study, aimed at exploring the feasibility of a large-scale trial of low-dose aspirin in polycythaemia vera (PV), 112 PV patients (42 females, 70 males, aged 17-80 years) were selected for not having a clear indication for, or contraindication to, aspirin treatment and randomized to receive oral aspirin (40 mg/d) or placebo. Follow-up duration was 16 ± 6 months. Measurements of thromboxane A2 production during whole blood clotting demonstrated complete inhibition of platelet cyclooxygenase activity in patients receiving aspirin. Aspirin administration was not associated with any bleeding complication. Within the limitations of the small sample size, this study indicates that a biochemically effective regimen of antiplatelet therapy is well tolerated in patients with polycythaemia vera and that a large-scale placebo-controlled trial is feasible.",

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AU - de Gaetano, G.

AU - Finazzi, G.

AU - Landolfi, Raffaele

AU - Marchioli, R.

AU - Patrono, C.

AU - Tognoni, G.

AU - Capani, F.

AU - De Carli, A.

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AU - Nenci, G. G.

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AU - Mandelli, F.

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AU - Barbui, T.

AU - Cortelazzo, S.

AU - Finazzi, G.

AU - Vestri, O.

AU - Tura, S.

AU - Finelli, C.

AU - Nocentini, F.

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AU - Di Blasio, A.

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AU - Kramer, V.

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