Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 23-30 |
| Number of pages | 8 |
| Journal | Lung Cancer |
| Volume | 131 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Asbestos-exposed
- Low-dose chest CT
- Lung cancer screening
- Lung-neoplasms
- Meta-analysis
- Pleural plaques
- Pleural thickening
- asbestos
- adult
- Article
- cancer mortality
- cancer risk
- cancer screening
- case control study
- computer assisted tomography
- controlled study
- female
- high risk population
- human
- interstitial lung disease
- lung cancer
- lung parenchyma
- major clinical study
- male
- middle aged
- occupational exposure
- pleura disease
- pleura plaque
- pleura thickening
- pleural calcification
- priority journal
- self report
- smoking
- workplace
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Low-dose computed tomography screening for lung cancer in people with workplace exposure to asbestos. / Maisonneuve, P.; Rampinelli, C.; Bertolotti, R.; Misotti, A.; Lococo, F.; Casiraghi, M.; Spaggiari, L.; Bellomi, M.; Novellis, P.; Solinas, M.; Dieci, E.; Alloisio, M.; Fontana, L.; Persechino, B.; Iavicoli, S.; Veronesi, G.
In: Lung Cancer, Vol. 131, 2019, p. 23-30.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Low-dose computed tomography screening for lung cancer in people with workplace exposure to asbestos
AU - Maisonneuve, P.
AU - Rampinelli, C.
AU - Bertolotti, R.
AU - Misotti, A.
AU - Lococo, F.
AU - Casiraghi, M.
AU - Spaggiari, L.
AU - Bellomi, M.
AU - Novellis, P.
AU - Solinas, M.
AU - Dieci, E.
AU - Alloisio, M.
AU - Fontana, L.
AU - Persechino, B.
AU - Iavicoli, S.
AU - Veronesi, G.
N1 - Cited By :3 Export Date: 27 February 2020 CODEN: LUCAE Correspondence Address: Maisonneuve, P.; Unit of Clinical Epidemiology, Division of Epidemiology and Biostatistics, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, Italy; email: patrick.maisonneuve@ieo.it Chemicals/CAS: asbestos, 1332-21-4 Funding details: Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro Funding text 1: This work was financed by INAIL as part of Research Activity Plan BRiC 2016 – ID56. ED and MS are recipients grants from the Umberto Veronesi foundation. The authors thank Don Ward for help with the English was added to the cases and non-cases to allow calculation of study weights and variance. Appendix A References: Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (2018) CA Cancer J. Clin., 68, pp. 394-424; Malarkey, D.E., Hoenerhoff, M., Maronpot, R.R., Carcinogenesis: mechanisms and manifestations (2013) Haschek and Rousseaux's Handbook of Toxicologic Pathology, p. 107. , W.M. Haschek C.G. Rousseaux M.A. Wallig Academic Press Waltham, MA; Prüss-Ustün, A., Wolf, J., Corvalán, C., Bos, R., Neira, M., Preventing Disease through Healthy Environments. A Global Assessment of the Burden of Disease from Environmental Risks (2016), World Health Organization WHO 92 4 156519 6; Doll, R., Peto, R., The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today (1981) J. Natl. Cancer Inst., 66, pp. 1191-1308; Nenonen, N., Hämäläinen, P., Takala, J., Saarela, K.L., Lim, S.L., Lim, G.K., Manickam, K., Global Estimates of Occupational Accidents and Fatal Work-related Diseases in 2014 based on 2010 and 2011 Data (2014), http://goo.gl/UlZorD, http://goo.gl/tN7XDn, Report to the ILO Tampere, Singapore, ILO Geneva and; Takala, J., Work-related Illnesses, Identification, Causal Factors and Prevention ‘safe Work – Healthy Work – for Life’ Greek EU Presidency Conference Athens, 16-17 June 2014 (2014); Loomis, D., Guha, N., Hall, A.L., Straif, K., Identifying occupational carcinogens: an update from the IARC Monographs (2018) Occup. Environ. Med., 75, pp. 593-603; Straif, K., The burden of occupational cancer (2008) Occup. Environ. Med., 65, pp. 787-788; National Lung Screening Trial Research Team, Aberle, D.R., Adams, A.M., Berg, C.D., Black, W.C., Clapp, J.D., Reduced lung-cancer mortality with low-dose computed tomographic screening (2011) N. Engl. J. Med., 365, pp. 395-409; De Koning, H., Van Der Aalst, C., Ten Haaf, K., Oudkerk, M., Effects of volume CT lung cancer screening: mortality results of the NELSON randomised-controlled population based trial (2018) Presented at: IASLC 19th World Conference on Lung Cancer, , https://wclc2018.iaslc.org/media/2018%20WCLC%20Press%20Program%20Press%20Release%20De%20Koning%209.25%20FINAL%20.pdf, Abstract PL02.05; Veronesi, G., Ajay, M., Mulshine, J.L., Pelosi, G., Scanagatta, P., Paganelli, G., Lung cancer screening with low-dose computed tomography: a non- -invasive diagnostic protocol for baseline lung nodules (2008) Lung Cancer, 61, pp. 340-349; Maisonneuve, P., Bagnardi, V., Ajay, M., Spaggiari, L., Pelosi, G., Rampinelli, C., Lung Cancer risk prediction for smokers to select screening CT - model based COSMOS on the Italian trial (2011) Cancer Prev. Res. (Phila), 4, pp. 1778-1789; Henschke, C.I., McCauley, D.I., Yankelevitz, D.F., Naidich, D.P., McGuinness, G., Miettinen, O.S., Early Lung Cancer action Project: overall design and findings from baseline screening (1999) Lancet, 354, pp. 99-105; Black, W.C., Gareen, I.F., Soneji, S.S., Sicks, J.D., Keeler, A.B., Abeler, D.R., Cost-effectiveness of CT screening in the national lung screening trial (2014) N. Engl. J. Med., 371, pp. 1793-1802; Veronesi, G., Maisonneuve, P., Spaggiari, L., Rampinelli, C., Pelosi, G., Preda, L., Long-term outcomes of a pilot CT screening for lung cancer (2010) Ecancermedicalscience, 4, p. 186; Wolff, H., Vehmas, T., Oksa, P., Rantanen, J., Vainio, H., Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations (2015) Scand. J. Work Environ. Health, 41, pp. 5-15; Bach, P.B., Kattan, M.W., Thornquist, M.D., Kris, M.G., Tate, R.C., Barnett, M.J., Variations in lung cancer risk among smokers (2003) J. Natl. Cancer Inst., 95, pp. 470-478; Cassidy, A., Myles, J.P., van Tongeren, M., Page, R.D., Liloglou, T., Duffy, S.W., The LLP risk model: an individual risk prediction model for lung cancer (2008) Br. J. Cancer, 98, pp. 270-276; Spitz, M.R., Hong, W.K., Amos, C.I., Wu, X., Schabath, M.B., Dong, Q., A risk model for prediction of lung cancer (2007) J. Natl. Cancer Inst., 99, pp. 715-726; Silva, M., Sverzellati, N., Colombi, D., Milanese, G., La Vecchia, C., Galeone, C., Pleural plaques in lung cancer screening by low-dose computed tomography: prevalence, association with lung cancer and mortality (2017) BMC Pulm. Med., 17, p. 155; Wallace, B.C., Schmid, C.H., Lau, J., Trikalinos, T.A., Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data (2009) BMC Med. Res. Methodol., 9, p. 80; Callol, L., Roig, F., Cuevas, A., de Granda, J.I., Villegas, F., Jareño, J., Low-dose CT: a useful and accessible tool for the early diagnosis of lung cancer in selected populations (2007) Lung Cancer, 56, pp. 217-221; Loewen, G., Natarajan, N., Tan, D., Nava, E., Klippenstein, D., Mahoney, M., Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment (2007) Thorax, 62, pp. 335-340; Greenberg, A.K., Lu, F., Goldberg, J.D., Eylers, E., Tsay, J.C., Yie, T.A., CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort (2012) PLoS One, 7; Pairon, J.C., Andujar, P., Rinaldo, M., Ameille, J., Brochard, P., Chamming's, S., Asbestos exposure, pleural plaques, and the risk of death from lung cancer (2014) Am. J. Respir. Crit. Care Med., 190, pp. 1413-1420; Felten, M.K., Knoll, L., Schikowsky, C., Das, M., Feldhaus, C., Hering, K.G., Is it useful to combine sputum cytology and low-dose spiral computed tomography for early detection of lung cancer in formerly asbestos-exposed power industry workers? (2014) J. Occup. Med. Toxicol., 9, p. 14; Carrillo, M.C., Alturkistany, S., Roberts, H., Nguyen, E., Chung, T.B., Paul, N., Low-dose computed tomography (LDCT) in workers previously exposed to asbestos: detection of parenchymal lung disease (2013) J. Comput. Assist. Tomogr., 37, pp. 626-630; Murray, C.P., Wong, P.M., The, J., de Klerk, N., Rosenow, T., Alfonso, H., Ultra low dose CT screen-detected non-malignant incidental findings in the Western Australian Asbestos Review Programme (2016) Respirology, 21, pp. 1419-1424; Mastrangelo, G., Ballarin, M.N., Bellini, E., Eder, M., Zannol, F., Gioffrè, F., Feasibility of a screening programme for lung cancer among workers previously heavily exposed to asbestos (2009) Med. Lav., 100, pp. 29-32; Lynch, D.A., Gamsu, G., Ray, C.S., Aberle, D.R., Asbestos-related focal lung masses: manifestations on conventional and high-resolution CT scans (1988) Radiology, 169, pp. 603-607; Tiitola, M., Kivisaari, L., Huuskonen, M.S., Mattson, K., Koskinen, H., Lehtola, H., Computed tomography screening for lung cancer in asbestos-exposed workers (2002) Lung Cancer, 35, pp. 17-22; Minniti, S., Valentini, M., Pozzi Mucelli, R., Low-dose helical chest CT in asbestos-exposed workers in the Veneto Region: preliminary results (2005) Radiol. Med., 110, pp. 317-324; Das, M., Mühlenbruch, G., Mahnken, A.H., Hering, K.G., Sirbu, H., Zschiesche, W., Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT (2007) Eur. Radiol., 17, pp. 1193-1199; Fasola, G., Belvedere, O., Aita, M., Zanin, T., Follador, A., Cassetti, P., Low-dose computed tomography screening for lung cancer and pleural mesothelioma in an asbestos-exposed population: baseline results of a prospective, nonrandomized feasibility trial–an Alpe-adria Thoracic Oncology Multidisciplinary Group Study (ATOM 002) (2007) Oncologist, 12, pp. 1215-1224; Vierikko, T., Järvenpää, R., Autti, T., Oksa, P., Huuskonen, M., Kaleva, S., Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings (2007) Eur. Respir. J., 29, pp. 78-84; Mastrangelo, G., Ballarin, M.N., Bellini, E., Bizzotto, R., Zannol, F., Gioffrè, F., Feasibility of a screening programme for lung cancer in former asbestos workers (2008) Occup. Med. (Lond), 58, pp. 175-180; Clin, B., Morlais, F., Guittet, L., Gislard, A., Marquignon, M.F., Paris, C., Performance of chest radiograph and CT scan for lung cancer screening in asbestos-exposed workers (2009) Occup. Environ. Med., 66, pp. 529-534; Roberts, H.C., Patsios, D.A., Paul, N.S., DePerrot, M., Teel, W., Bayanati, H., Screening for malignant pleural mesothelioma and lung cancer in individuals with a history of asbestos exposure (2009) J. Thorac. Oncol., 4, pp. 620-628; Pira, E., Coggiola, M., Bosio, D., Early lung cancer detection in an occupational asbestos exposed population: clinical impact of low-dose computed tomography screening (2010) G. Ital. Med. Lav. Ergon., 32, pp. 389-393; Clin, B., Luc, A., Morlais, F., Paris, C., Ameille, J., Brochard, P., Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance (2011) Int. J. Tuberc. Lung Dis., 15, pp. 1707-1714; Brims, F.J., Murray, C.P., de Klerk, N., Alfonso, H., Reid, A., Manners, D., Ultra-low-dose chest computer tomography screening of an asbestos-exposed population in Western Australia (2015) Am. J. Respir. Crit. Care Med., 191, pp. 113-116; Lee, E.K., Kim, J.S., Kim, Y., Park, J.S., CT findings in people who were environmentally exposed to asbestos in Korea (2015) J. Korean Med. Sci., 30, pp. 1896-1901; Schaal, M., Severac, F., Labani, A., Jeung, M.Y., Roy, C., Ohana, M., Diagnostic performance of ultra-low-Dose computed tomography for detecting asbestos-related pleuropulmonary diseases: prospective study in a screening setting (2016) PLoS One, 11; Kato, K., Gemba, K., Ashizawa, K., Arakawa, H., Honda, S., Noguchi, N., Low-dose chest computed tomography screening of subjects exposed to asbestos (2018) Eur. J. Radiol., 101, pp. 124-128; Corfiati, M., Scarselli, A., Binazzi, A., Di Marzio, D., Verardo, M., Mirabelli, D., ReNaM Working Group. Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry (2015) BMC Cancer, 15, p. 286; Tossavainen, A., Asbestos, asbestosis, and cancer: the Helsinki criteria for diagnosis and attribution (1997) Scand. J. Work Environ. Health, 23, pp. 311-316. , reporter; Pairon, J.C., Andujar, P., Rinaldo, M., Ameille, J., Brochard, P., Chamming's, S., Asbestos exposure, pleural plaques, and the risk of death from lung cancer (2014) Am. J. Respir. Crit. Care Med., 190, pp. 1413-1420; Mazzei, M.A., Contorni, F., Gentili, F., Guerrini, S., Mazzei, F.G., Pinto, A., Incidental and underreported pleural plaques at chest CT: do not miss them-asbestos exposure still exists (2017) Biomed Res. Int., 2017; Maxim, L.D., Niebo, R., Utell, M.J., Are pleural plaques an appropriate endpoint for risk analyses? (2015) Inhal. Toxicol., 27, pp. 321-334; Pairon, J.C., Laurent, F., Rinaldo, M., Clin, B., Andujar, P., Ameille, J., Pleural plaques and the risk of pleural mesothelioma (2013) J. Natl. Cancer Inst., 105, pp. 293-301; Mastrangelo, G., Marangi, G., Ballarin, M.N., Fadda, E., Scoizzato, L., Fedeli, U., Lung cancer risk in past asbestos workers a few decades after exposure cessation and prospects for screening (2016) Arch. Environ. Occup. Health, 71, pp. 237-244; Marinaccio, A., Binazzi, A., Di Marzio, D., Scarselli, A., Verardo, M., Mirabelli, D., Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register (2010) Occup. Environ. Med., 67, pp. 760-765
PY - 2019
Y1 - 2019
N2 - Objectives: Smoking is the main risk factor for lung cancer, but environmental and occupational exposure to carcinogens also increase lung cancer risk. We assessed whether extending low-dose computed tomography (LDCT) screening to persons with occupational exposure to asbestos may be an effective way reducing lung cancer mortality. Materials and methods: We conducted a nested case-control study within the COSMOS screening program, assessing past asbestos exposure with a questionnaire. LDCT scans of asbestos-exposed participants were reviewed to assess the presence of pulmonary, interstitial and pleural alterations in comparison to matched unexposed controls. We also performed an exhaustive review, with meta-analysis, of the literature on LDCT screening in asbestos-exposed persons. Results: Exposure to asbestos, initially self-reported by 9.8% of COSMOS participants, was confirmed in 216 of 544 assessable cases, corresponding to 2.6% of the screened population. LDCT of asbestos-exposed persons had significantly more pleural plaques, diaphragmatic pleural thickening and pleural calcifications, but similar frequency of parenchymal and interstitial alterations to unexposed persons. From 16 papers, including this study, overall lung cancer detection rates at baseline were 0.81% (95% CI 0.50–1.19) in asbestos-exposed persons, 0.94% (95% CI 0.47–1.53) in asbestos-exposed smokers (12 studies), and 0.11% (95% CI 0.00-0.43) in asbestos-exposed non-smokers (9 studies). Conclusion: Persons occupationally exposed to asbestos should be monitored to gather more information about risks. Although LDCT screening is effective in the early detection lung cancer in asbestos-exposed smokers, our data suggest that screening of asbestos-exposed persons with no additional risk factors for cancer does is not viable due to the low detection rate. © 2019 Elsevier B.V.
AB - Objectives: Smoking is the main risk factor for lung cancer, but environmental and occupational exposure to carcinogens also increase lung cancer risk. We assessed whether extending low-dose computed tomography (LDCT) screening to persons with occupational exposure to asbestos may be an effective way reducing lung cancer mortality. Materials and methods: We conducted a nested case-control study within the COSMOS screening program, assessing past asbestos exposure with a questionnaire. LDCT scans of asbestos-exposed participants were reviewed to assess the presence of pulmonary, interstitial and pleural alterations in comparison to matched unexposed controls. We also performed an exhaustive review, with meta-analysis, of the literature on LDCT screening in asbestos-exposed persons. Results: Exposure to asbestos, initially self-reported by 9.8% of COSMOS participants, was confirmed in 216 of 544 assessable cases, corresponding to 2.6% of the screened population. LDCT of asbestos-exposed persons had significantly more pleural plaques, diaphragmatic pleural thickening and pleural calcifications, but similar frequency of parenchymal and interstitial alterations to unexposed persons. From 16 papers, including this study, overall lung cancer detection rates at baseline were 0.81% (95% CI 0.50–1.19) in asbestos-exposed persons, 0.94% (95% CI 0.47–1.53) in asbestos-exposed smokers (12 studies), and 0.11% (95% CI 0.00-0.43) in asbestos-exposed non-smokers (9 studies). Conclusion: Persons occupationally exposed to asbestos should be monitored to gather more information about risks. Although LDCT screening is effective in the early detection lung cancer in asbestos-exposed smokers, our data suggest that screening of asbestos-exposed persons with no additional risk factors for cancer does is not viable due to the low detection rate. © 2019 Elsevier B.V.
KW - Asbestos-exposed
KW - Low-dose chest CT
KW - Lung cancer screening
KW - Lung-neoplasms
KW - Meta-analysis
KW - Pleural plaques
KW - Pleural thickening
KW - asbestos
KW - adult
KW - Article
KW - cancer mortality
KW - cancer risk
KW - cancer screening
KW - case control study
KW - computer assisted tomography
KW - controlled study
KW - female
KW - high risk population
KW - human
KW - interstitial lung disease
KW - lung cancer
KW - lung parenchyma
KW - major clinical study
KW - male
KW - middle aged
KW - occupational exposure
KW - pleura disease
KW - pleura plaque
KW - pleura thickening
KW - pleural calcification
KW - priority journal
KW - self report
KW - smoking
KW - workplace
U2 - 10.1016/j.lungcan.2019.03.003
DO - 10.1016/j.lungcan.2019.03.003
M3 - Article
VL - 131
SP - 23
EP - 30
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
ER -