Abstract
Thirthy-six patients with refractory anemia with excess of blasts in transformation (RAEBt), or acute myelogenous leukemia (AML) after myelodysplastic syndrome, and twenty-four patients with 'de novo' AML were treated with cytosine arabinoside (Ara-C) in low dosage. The two groups of patients were comparable with respect to age, hemoglobin level, white cell and platelet counts. Ara-C was administered subcutaneously at a dose of 10 mg/m2 every 12 hours for 21 days. Treatments were repeated every 2-3 months depending on marrow cellularity. Overall, 30% complete response and 48% partial response were observed. Neutropenia and thrombocytopenia were frequent complications. Median survival from the start of treatment was 7 months in both groups; at least 25% of patients survived more than 12 months. Survival appeared to be related to treatment response: patients achieving complete remission survived significantly longer than those who had partial remission.
Original language | English |
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Pages (from-to) | 61-65 |
Number of pages | 5 |
Journal | Haematologica |
Volume | 72 |
Issue number | 1 |
Publication status | Published - 1987 |
ASJC Scopus subject areas
- Hematology