Low-dose dobutamine test associated with interventricular dyssynchrony

A useful tool to identify cardiac resynchronization therapy responders: Data from the LOw dose DObutamine stress-echo test in Cardiac Resynchronization Therapy (LODO-CRT) phase 2 study

Maurizio Gasparini, Carmine Muto, Saverio Iacopino, Francesco Zanon, Cosimo Dicandia, Giuseppe Distefano, Stefano Favale, Carlo Peraldo Neja, Renato Bragato, Mario Davinelli, Lorenza Mangoni, Alessandra Denaro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Cardiac resynchronization therapy (CRT) is effective in patients with heart failure, but 30% to 50% of subjects are classified as nonresponders. Identifying responders remains a challenging task. Aims: The LODO-CRT trial investigated the association between left ventricular contractile reserve (LVCR) and clinical and echocardiographic long-term CRT response. Methods: This is a multicenter, prospective, observational study. Left ventricular contractile reserve was detected using a dobutamine stress echocardiography test, defined as an ejection fraction increase of >5 points. Clinical CRT response was defined as the absence of major cardiovascular events (ie, cardiovascular death or heart failure hospitalization). Echocardiographic response was defined as a left ventricle end-systolic volume reduction of >10%. Results: A total of 221 CRT-indicated patients were studied (80% presented LVCR). During a mean follow-up of 15 ± 5 months, 17 patients died and 16 were hospitalized due to heart failure. The proportion of clinical responders was 155 (88%) of 177 and 33 (75%) of 44 (P =.036) in the groups with and without LVCR, respectively. Kaplan-Meier analysis showed a significant difference in cardiac survival/hospitalization between patients with and without LVCR. The proportion of echocardiographic responders was 144 (87%) of 166 and 16 (42%) of 38 in the groups with and without LVCR (P

Original languageEnglish
Pages (from-to)422-429
Number of pages8
JournalAmerican Heart Journal
Volume163
Issue number3
DOIs
Publication statusPublished - Mar 2012

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Cardiac Resynchronization Therapy
Dobutamine
Exercise Test
Heart Failure
Hospitalization
Stress Echocardiography
Kaplan-Meier Estimate
Heart Ventricles
Observational Studies
Prospective Studies
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Low-dose dobutamine test associated with interventricular dyssynchrony : A useful tool to identify cardiac resynchronization therapy responders: Data from the LOw dose DObutamine stress-echo test in Cardiac Resynchronization Therapy (LODO-CRT) phase 2 study. / Gasparini, Maurizio; Muto, Carmine; Iacopino, Saverio; Zanon, Francesco; Dicandia, Cosimo; Distefano, Giuseppe; Favale, Stefano; Peraldo Neja, Carlo; Bragato, Renato; Davinelli, Mario; Mangoni, Lorenza; Denaro, Alessandra.

In: American Heart Journal, Vol. 163, No. 3, 03.2012, p. 422-429.

Research output: Contribution to journalArticle

Gasparini, Maurizio ; Muto, Carmine ; Iacopino, Saverio ; Zanon, Francesco ; Dicandia, Cosimo ; Distefano, Giuseppe ; Favale, Stefano ; Peraldo Neja, Carlo ; Bragato, Renato ; Davinelli, Mario ; Mangoni, Lorenza ; Denaro, Alessandra. / Low-dose dobutamine test associated with interventricular dyssynchrony : A useful tool to identify cardiac resynchronization therapy responders: Data from the LOw dose DObutamine stress-echo test in Cardiac Resynchronization Therapy (LODO-CRT) phase 2 study. In: American Heart Journal. 2012 ; Vol. 163, No. 3. pp. 422-429.
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AU - Gasparini, Maurizio

AU - Muto, Carmine

AU - Iacopino, Saverio

AU - Zanon, Francesco

AU - Dicandia, Cosimo

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AU - Favale, Stefano

AU - Peraldo Neja, Carlo

AU - Bragato, Renato

AU - Davinelli, Mario

AU - Mangoni, Lorenza

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