Recombinant interleukin-2 (rIL-2) can produce impairment of renal function with hypotension, fluid retention, elevated blood urea nitrogen, oliguria and low fractional sodium excretion; these side-effects are a common cause of reduction or interruption of rIL-2 infusion. The aim of this study was to investigate the control and treatment of renal toxicity induced by rIL-2 therapy. Here we show that dopamine, at a low dose of 2 μg/kg/min, completely prevented renal toxicity induced by rIL-2. While continuing rIL-2 therapy, 24-h continuous infusion of low-dose dopamine produced a rapid normalisation of urine output and a significant decrease in serum creatinine levels and body weight (P <0.01), with an early and complete recovery of the rIL-2-impaired renal function: mean recovery time of renal function in patients treated with dopamine was significantly lower (P <0.05) than in non-treated patients (4.8 days vs. 10 days, respectively).
ASJC Scopus subject areas
- Cancer Research