Abstract
Developmental health risks of chronical exposure to low doses of foodborne persistent organic pollutants (POP) are recognized but still largely uncharacterized. Juvenile female BALB/c mice exposed to either HBCD, CB-153 or TCDD at doses relevant to human dietary exposures (49.5 μg, 1.35 μg and 0.90 ng kg −1 bw −1 day −1 , respectively) for 28 days displayed histopathological changes in liver (HBCD, CB-153, TCDD), thymus (HBCD, CB-153) and uterus (HBCD), reduced serum oestradiol 17β (E2) levels (HBCD), increased serum testosterone (T) levels (CB-153) and an increased T/E2 ratio (HBCD). Proteomics analysis of brain provided molecular support for the HBCD-induced reduction in E2. Neural gene expression analysis, confirmed effects on 18 out of 30 genes previously found to be affected after exposure to higher doses to the same pollutants. Our findings indicate that exposure to POP at low doses is associated with subtle, but toxicological relevant effects on post-natal development in female mice.
| Original language | English |
|---|---|
| Pages (from-to) | 105-116 |
| Number of pages | 12 |
| Journal | Reproductive Toxicology |
| Volume | 80 |
| DOIs | |
| Publication status | Published - Sep 1 2018 |
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Keywords
- Calcium
- Endocrine disruption
- G6PD
- Liver
- Neurotoxicity
- Oestradiol
- POP
- Zinc
ASJC Scopus subject areas
- Toxicology
Cite this
Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice. / Rasinger, J. D.; Carroll, T. S.; Maranghi, F.; Tassinari, R.; Moracci, G.; Altieri, I.; Mantovani, A.; Lundebye, A. K.; Hogstrand, C.
In: Reproductive Toxicology, Vol. 80, 01.09.2018, p. 105-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice
AU - Rasinger, J. D.
AU - Carroll, T. S.
AU - Maranghi, F.
AU - Tassinari, R.
AU - Moracci, G.
AU - Altieri, I.
AU - Mantovani, A.
AU - Lundebye, A. K.
AU - Hogstrand, C.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Developmental health risks of chronical exposure to low doses of foodborne persistent organic pollutants (POP) are recognized but still largely uncharacterized. Juvenile female BALB/c mice exposed to either HBCD, CB-153 or TCDD at doses relevant to human dietary exposures (49.5 μg, 1.35 μg and 0.90 ng kg −1 bw −1 day −1 , respectively) for 28 days displayed histopathological changes in liver (HBCD, CB-153, TCDD), thymus (HBCD, CB-153) and uterus (HBCD), reduced serum oestradiol 17β (E2) levels (HBCD), increased serum testosterone (T) levels (CB-153) and an increased T/E2 ratio (HBCD). Proteomics analysis of brain provided molecular support for the HBCD-induced reduction in E2. Neural gene expression analysis, confirmed effects on 18 out of 30 genes previously found to be affected after exposure to higher doses to the same pollutants. Our findings indicate that exposure to POP at low doses is associated with subtle, but toxicological relevant effects on post-natal development in female mice.
AB - Developmental health risks of chronical exposure to low doses of foodborne persistent organic pollutants (POP) are recognized but still largely uncharacterized. Juvenile female BALB/c mice exposed to either HBCD, CB-153 or TCDD at doses relevant to human dietary exposures (49.5 μg, 1.35 μg and 0.90 ng kg −1 bw −1 day −1 , respectively) for 28 days displayed histopathological changes in liver (HBCD, CB-153, TCDD), thymus (HBCD, CB-153) and uterus (HBCD), reduced serum oestradiol 17β (E2) levels (HBCD), increased serum testosterone (T) levels (CB-153) and an increased T/E2 ratio (HBCD). Proteomics analysis of brain provided molecular support for the HBCD-induced reduction in E2. Neural gene expression analysis, confirmed effects on 18 out of 30 genes previously found to be affected after exposure to higher doses to the same pollutants. Our findings indicate that exposure to POP at low doses is associated with subtle, but toxicological relevant effects on post-natal development in female mice.
KW - Calcium
KW - Endocrine disruption
KW - G6PD
KW - Liver
KW - Neurotoxicity
KW - Oestradiol
KW - POP
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=85049524732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049524732&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2018.06.010
DO - 10.1016/j.reprotox.2018.06.010
M3 - Article
C2 - 29935226
AN - SCOPUS:85049524732
VL - 80
SP - 105
EP - 116
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
SN - 0890-6238
ER -