Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

J. D. Rasinger, T. S. Carroll, F. Maranghi, R. Tassinari, G. Moracci, I. Altieri, A. Mantovani, A. K. Lundebye, C. Hogstrand

Research output: Contribution to journalArticle

Abstract

Developmental health risks of chronical exposure to low doses of foodborne persistent organic pollutants (POP) are recognized but still largely uncharacterized. Juvenile female BALB/c mice exposed to either HBCD, CB-153 or TCDD at doses relevant to human dietary exposures (49.5 μg, 1.35 μg and 0.90 ng kg −1 bw −1 day −1 , respectively) for 28 days displayed histopathological changes in liver (HBCD, CB-153, TCDD), thymus (HBCD, CB-153) and uterus (HBCD), reduced serum oestradiol 17β (E2) levels (HBCD), increased serum testosterone (T) levels (CB-153) and an increased T/E2 ratio (HBCD). Proteomics analysis of brain provided molecular support for the HBCD-induced reduction in E2. Neural gene expression analysis, confirmed effects on 18 out of 30 genes previously found to be affected after exposure to higher doses to the same pollutants. Our findings indicate that exposure to POP at low doses is associated with subtle, but toxicological relevant effects on post-natal development in female mice.

Original languageEnglish
Pages (from-to)105-116
Number of pages12
JournalReproductive Toxicology
Volume80
DOIs
Publication statusPublished - Sep 1 2018

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Keywords

  • Calcium
  • Endocrine disruption
  • G6PD
  • Liver
  • Neurotoxicity
  • Oestradiol
  • POP
  • Zinc

ASJC Scopus subject areas

  • Toxicology

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