Abstract
Heparin, after subcutaneous administration, has been found to be able to bind to endothelial receptors both in rabbits and in humans. N-sulphonate 35S-heparin remains bound in rabbits for at least 24 h and is able to enhance the inactivation process of thrombin and factor Xa. Heparin subcutaneously (200 U/kg) injected for 2 weeks resulted in an enhanced inactivation of thrombin and factor Xa by the endothelium. The antithrombin- enhancing activity persists longer than the anti-Xa activity. In man, daily subcutaneous administration of heparin (12,500 U/day) for 2 weeks significantly reduces the increased fibrinopeptide A plasma levels and normalizes the increased l25I-fibrinogen turnover. The present work indicates that heparin administration at a low dose represents a treatment able to remarkably enhance the antithrombotic properties of the vessel wall, independently of the presence of detectable heparin levels in the circulating blood.
Original language | English |
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Pages (from-to) | 129-131 |
Number of pages | 3 |
Journal | Pathophysiology of Haemostasis and Thrombosis |
Volume | 20 |
DOIs | |
Publication status | Published - 1990 |
Keywords
- Anti-Xa activity
- Antithrombin
- Endothelium
- Heparin-antithrombotic therapy
ASJC Scopus subject areas
- Hematology
- Physiology (medical)