Low-dose "metronomic chemotherapy" with oral cyclophosphamide and methotrexate in metastatic breast cancer: A case report of extraordinarily prolonged clinical benefit

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Abstract

We report the case of a 34-year-old woman affected by breast cancer that had metastasized to the bone. She had been treated with oral cyclophosphamide and methotrexate (metronomic chemotherapy) and achieved 3.5 years of clinical remission. To our knowledge, this is the first description of such a prolonged response to therapy. This case report adds weight to known data on metronomic treatment and supports further investigation of this therapy.

Original languageEnglish
Article number275
Journalecancermedicalscience
Volume6
Issue number1
DOIs
Publication statusPublished - Oct 18 2012

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Methotrexate
Cyclophosphamide
Breast Neoplasms
Drug Therapy
Therapeutics
Weights and Measures
Bone and Bones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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AU - Losurdo, A.

AU - Gandini, C.

AU - Garassino, I.

AU - Di Tommaso, L.

AU - Torrisi, R.

AU - Zuradelli, M.

AU - Santoro, A.

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