Low-dose 'natural' alpha-interferon in B-cell derived chronic lymphocytic leukemia

G. Pozzato; F. Franzin; M. Moretti; P. Tulissi; P. Pecorari; M. Melato; T. Zacchi; P. Evangelisti; L. Campanacci

Low-dose 'natural' alpha-interferon in B-cell derived chronic lymphocytic leukemia

G. Pozzato, F. Franzin, M. Moretti, P. Tulissi, P. Pecorari, M. Melato, T. Zacchi, P. Evangelisti, L. Campanacci

IRCCS pediatrico Burlo Garofolo

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Abstract

Background. Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose 'natural' IFN was evaluated in terms of efficacy and safety. Methods. Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months. Results. Overall lymphocyte count decreased from 13.050 ± 3.200 to 7.500 ± 2.940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects. Conclusion: Low dose 'natural' alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.

Original language	English
Pages (from-to)	413-417
Number of pages	5
Journal	Haematologica
Volume	77
Issue number	5
Publication status	Published - 1992

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Hematology

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Pozzato, G., Franzin, F., Moretti, M., Tulissi, P., Pecorari, P., Melato, M., Zacchi, T., Evangelisti, P., & Campanacci, L. (1992). Low-dose 'natural' alpha-interferon in B-cell derived chronic lymphocytic leukemia. Haematologica, 77(5), 413-417.

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abstract = "Background. Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose 'natural' IFN was evaluated in terms of efficacy and safety. Methods. Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months. Results. Overall lymphocyte count decreased from 13.050 ± 3.200 to 7.500 ± 2.940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects. Conclusion: Low dose 'natural' alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.",

author = "G. Pozzato and F. Franzin and M. Moretti and P. Tulissi and P. Pecorari and M. Melato and T. Zacchi and P. Evangelisti and L. Campanacci",

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TY - JOUR

T1 - Low-dose 'natural' alpha-interferon in B-cell derived chronic lymphocytic leukemia

AU - Pozzato, G.

AU - Franzin, F.

AU - Moretti, M.

AU - Tulissi, P.

AU - Pecorari, P.

AU - Melato, M.

AU - Zacchi, T.

AU - Evangelisti, P.

AU - Campanacci, L.

PY - 1992

Y1 - 1992

N2 - Background. Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose 'natural' IFN was evaluated in terms of efficacy and safety. Methods. Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months. Results. Overall lymphocyte count decreased from 13.050 ± 3.200 to 7.500 ± 2.940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects. Conclusion: Low dose 'natural' alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.

AB - Background. Alpha-interferon (alpha-IFN) was found to have a good antiproliferative effect in early stage chronic lymphocytic leukemia (CLL), but recombinant alpha-IFN administration may induce serious side effects. Therefore low-dose 'natural' IFN was evaluated in terms of efficacy and safety. Methods. Fifteen patients affected by stage A (according to Binet) B-CLL underwent the treatment: natural IFN 1 MU three times a week for 6 months. Results. Overall lymphocyte count decreased from 13.050 ± 3.200 to 7.500 ± 2.940 within 6 months. One patient did not respond to IFN therapy. No one complained of side effects. Conclusion: Low dose 'natural' alpha-IFN seems useful and well tolerated in CLL, but the potential curative role of IFN in CLL remains to be established.

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Low-dose 'natural' alpha-interferon in B-cell derived chronic lymphocytic leukemia

Abstract

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