Low-dose neuroleptic therapy and relapse in schizophrenia: Meta-analysis of randomized controlled trials

C. Barbui, B. Saraceno, A. Liberati, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the relative efficacy and effectiveness of low-versus standard-dose neuroleptic therapy in reducing relapse rate in schizophrenic patients. Six long-term randomized controlled trials were retrieved through a MEDLINE search. A dose regimen between 50 and 100 mg equivalent of chlorpromazine, compared to a conventional one between 200 and 500 mg, was found to increase the likelihood of relapse in chronic schizophrenic patients. Differences, however, were statistically significant at 12 but not at 24 months of treatment.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalEuropean Psychiatry
Volume11
Issue number6
DOIs
Publication statusPublished - 1996

Keywords

  • Low-dose
  • Meta-analysis
  • Neuroleptics
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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