Low dose of insulin for assessment of growth hormone and cortisol release in short children

Mauro Bozzola, Patrizia Comoli, Elena Bozzola, Carmine Tinelli, Annalisa Marello, Milena Stabile, Alessandra Mazzola, Vittorio Locatelli

Research output: Contribution to journalArticle


Objective: In 55 prepubertal children with growth failure, aged 8.62 ± 2.89 years, we evaluated the efficacy of a test using only half the usual dose of insulin by comparing the results with those obtained during a classical arginine tolerance test, performed separately. Patients and Methods: The patients were randomly divided into two groups: group A consisting of 37 children received 0.05 U/kg insulin, while group B consisting of 18 patients received 0.1 U/kg insulin. Each child received the same dose of arginine per kg during the second test. Results: Serum growth hormone (GH) peak levels were significantly (p

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number8
Publication statusPublished - Aug 2005



  • Children
  • Cortisol
  • Glycaemia
  • Growth hormone
  • Growth hormone deficiency
  • Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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