Low dose oral administration of cytokines for treatment of allergic asthma

Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Giuseppina F. Dusio, Valentina Mauro, Umberto Solimene, Diego Cardani, Martina Mantovani, Cristiano Rumio

Research output: Contribution to journalArticlepeer-review

Abstract

Many inflammatory diseases are characterized by an imbalance among lymphocyte populations, in particular Th1, Th2 and the recently described Th17 cells. The Th1/Th2 imbalance is linked to many factors, but certainly the role of cytokines is essential. In Th2 diseases IL-4 expression is predominant, while Th1 pathologies are characterized by high expression of IFN-γ and IL-12. Though today the therapeutical proposal for many inflammatory diseases aims to re-establish normal levels of Th1/Th2 cytokines, the pharmacological use of cytokines, which are very active molecules, is limited by the possible collateral effects. Therefore, our study aims to determine, in a murine model of allergic asthma, the possible therapeutic activity of low dose cytokines solutions, mechanically activated. We found that oral administration of low doses IL-12 plus IFN-γ is able to solve the bronchial hyperresponsiveness condition of mice, establishing normal cytokine levels. The anti-asthma activity was confirmed by histological analysis of lungs and broncho-alveolar lavage fluid cell count. Serum ovalbumin-specific IgE was also significantly inhibited by treatment with low dose activated cytokines solution. These findings may suggest a novel approach to diseases which involve a Th1/Th2 imbalance.

Original languageEnglish
Pages (from-to)497-510
Number of pages14
JournalPulmonary Pharmacology and Therapeutics
Volume22
Issue number6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Allergy
  • Cytokines
  • IFN-γ
  • IL-12
  • Lung
  • Mouse
  • Th1/Th2 Cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

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