TY - JOUR
T1 - Low-dose oral fludarabine plus cyclophosphamide as first-line treatment in elderly patients with indolent non-Hodgkin lymphoma
AU - Fabbri, Alberto
AU - Lenoci, Mariapia
AU - Gozzetti, Alessandro
AU - Chitarrelli, Ida
AU - Olcese, Francesca
AU - Raspadori, Donatella
AU - Gobbi, Marco
AU - Lauria, Francesco
PY - 2007/10
Y1 - 2007/10
N2 - Twenty-five elderly patients with untreated indolent non-Hodgkin lymphoma were treated with oral fludarabine 25 mg/m2/d (40 mg total dose) and cyclophosphamide 150 mg/m2/d, both for four consecutive days, repeated every 28 d for four cycles. In all, 21 (84%) patients were responsive: 10 patients achieved complete remission while partial response was obtained in 11. During an observation period of 37 months, there was an overall survival rate of 70% and a median event-free survival of 20 months. Haematological and extra-haematological toxicity were mild. This reduced-dose Flu-based oral regimen showed good efficacy and was simple to administer on an outpatient basis.
AB - Twenty-five elderly patients with untreated indolent non-Hodgkin lymphoma were treated with oral fludarabine 25 mg/m2/d (40 mg total dose) and cyclophosphamide 150 mg/m2/d, both for four consecutive days, repeated every 28 d for four cycles. In all, 21 (84%) patients were responsive: 10 patients achieved complete remission while partial response was obtained in 11. During an observation period of 37 months, there was an overall survival rate of 70% and a median event-free survival of 20 months. Haematological and extra-haematological toxicity were mild. This reduced-dose Flu-based oral regimen showed good efficacy and was simple to administer on an outpatient basis.
KW - Cyclophosphamide
KW - Elderly
KW - Indolent non-Hoddgkin lymphoma
KW - Low-dose
KW - Oral fludarabine
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U2 - 10.1111/j.1365-2141.2007.06746.x
DO - 10.1111/j.1365-2141.2007.06746.x
M3 - Article
C2 - 17854311
AN - SCOPUS:34548567362
VL - 139
SP - 90
EP - 93
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -